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dc.contributor.author
Aguilera Braico, Diego Máximo
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dc.contributor.author
Roldán Deamicis, Agustina
dc.contributor.author
Brie, Belen
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dc.contributor.author
Balogh, Gabriela Andrea
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dc.date.available
2018-05-08T20:42:16Z
dc.date.issued
2017-03
dc.identifier.citation
Aguilera Braico, Diego Máximo; Roldán Deamicis, Agustina; Brie, Belen; Balogh, Gabriela Andrea; Comparative Effect of Maitake Pro4x with Chemotherapy Breast Cancer Treatment; Omics International; Biology and Medicine; 9; 3; 3-2017; 1-8;1000394
dc.identifier.issn
0974-8369
dc.identifier.uri
http://hdl.handle.net/11336/44513
dc.description.abstract
Conventional treatments for breast cancer involve surgery followed by radiation and hormonal therapy and/or chemotherapy. Some of these treatments have toxic side effects. Because drugs used in chemotherapy affect both cancer and normal cells to varying degrees, researchers are currently developing targeted drugs that only attack cancer cells without affecting normal cells. One approach to this is to found compounds that are more selective and specific, destroying only tumour cells and prevent metastases without harming normal cells. For thousands of years, medicinal mushrooms have been used because of their healing properties. Maitake (Grifola frondosa) is one of the most promising edible and medicinal mushroom, acting promoting the immune system against the tumorigenesis process. Methods: In the in vitro studies, we measured and compared the effect of Maitake Pro4X or Chemotherapy on LM3 Breast Tumour Cells death. Increased concentrations and different time of treatments were employed. In the in vivo studies, we employed breast tumour bearing female BALBc mice 6-8 weeks old, to assayed the effect of Maitake Pro4X with or without chemotherapy measuring the tumour volume, mortality, relative survival and size of tumour necrosis area after treatment. Results: After 5 weeks of treatment in tumour-bearing BALBc mice, we observed that Maitake Pro4X significantly increased the overall survival of animals and reduced the malignancy of breast tumours. We also found that Maitake Pro4X, as chemotherapy, induce cell-death in a dose and time dependent form. Conclusion: The beneficial effects of Maitake D-Fraction Pro4X, if supported by further evidence could be useful for the treatment of cancer patients to reduce the adverse effects of the conventional chemotherapy treatment.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Omics International
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Maitake
dc.subject
Chemotherapy
dc.subject
Breast Cancer
dc.subject
Survival
dc.subject.classification
Otras Ciencias Biológicas
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Comparative Effect of Maitake Pro4x with Chemotherapy Breast Cancer Treatment
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-04-18T17:42:52Z
dc.journal.volume
9
dc.journal.number
3
dc.journal.pagination
1-8;1000394
dc.journal.pais
Estados Unidos
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dc.description.fil
Fil: Aguilera Braico, Diego Máximo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Ciencias de la Salud; Argentina
dc.description.fil
Fil: Roldán Deamicis, Agustina. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Instituto de Investigaciones Biomédicas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina
dc.description.fil
Fil: Brie, Belen. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Instituto de Investigaciones Biomédicas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina
dc.description.fil
Fil: Balogh, Gabriela Andrea. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Instituto de Investigaciones Biomédicas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina
dc.journal.title
Biology and Medicine
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.omicsonline.org/open-access/comparative-effect-of-maitake-pro4x-with-chemotherapy-breast-cancer-treatment-0974-8369-1000394.php?aid=87861
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.4172/0974-8369.1000394
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