Artículo
Genetic Variations in the TP53 Pathway in Native Americans Strongly Suggest Adaptation to the High Altitudes of the Andes
Jacovas, Vanessa Cristina; Rovaris, Diego Luiz; Perez, Luis Orlando
; de Azevedo, Soledad
; Souza Macedo, Gabriel; Sandoval, José Raul; Salazar Granara, Alberto; Villena, Mercedes; Dugoujon, Jean Michel; Bisso Machado, Rafael; Petzl Erler, Maria Luiza; Salzano, Francisco Mauro; Ashton Prolla, Patrícia; Ramallo, Virginia
; Bortolini, Maria Catira
Fecha de publicación:
09/2015
Editorial:
Public Library of Science
Revista:
Plos One
ISSN:
1932-6203
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
The diversity of the five single nucleotide polymorphisms located in genes of the TP53 pathway (TP53, rs1042522; MDM2, rs2279744; MDM4, rs1563828; USP7, rs1529916; and LIF, rs929271) were studied in a total of 282 individuals belonging to Quechua, Aymara, Chivay, Cabanaconde, Yanke, Taquile, Amantani, Anapia, Uros, Guarani Ñandeva, and Guarani Kaiowá populations, characterized as Native American or as having a high level (> 90%) of Native American ancestry. In addition, published data pertaining to 100 persons from five other Native American populations (Surui, Karitiana, Maya, Pima, and Piapoco) were analyzed. The populations were classified as living in high altitude (≥ 2,500 m) or in lowlands (< 2,500 m). Our analyses revealed that alleles USP7-G, LIF-T, and MDM2-T showed significant evidence that they were selected for in relation to harsh environmental variables related to high altitudes. Our results show for the first time that alleles of classical TP53 network genes have been evolutionary co-opted for the successful human colonization of the Andes.
Palabras clave:
Tp53 Pathway
,
Human Adaptation High Altitude
,
Native American
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Articulos(CCT-CENPAT)
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - CENPAT
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - CENPAT
Citación
Jacovas, Vanessa Cristina; Rovaris, Diego Luiz; Perez, Luis Orlando; de Azevedo, Soledad; Souza Macedo, Gabriel; et al.; Genetic Variations in the TP53 Pathway in Native Americans Strongly Suggest Adaptation to the High Altitudes of the Andes; Public Library of Science; Plos One; 10; 9; 9-2015; 1-15
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