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dc.contributor.author
Hessell, Ann J.
dc.contributor.author
Jaworski, Juan Pablo
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dc.contributor.author
Epson, Erin
dc.contributor.author
Matsuda, Kenta
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Pandey, Shilpi
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Kahl, Christoph
dc.contributor.author
Reed, Jason
dc.contributor.author
Sutton, William F.
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Hammond, Katherine B.
dc.contributor.author
Cheever, Tracy A.
dc.contributor.author
Barnette, Philip T.
dc.contributor.author
Legasse, Alfred W.
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Planer, Shannon
dc.contributor.author
Stanton, Jeffrey J.
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Pegu, Amarendra
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Chen, Xuejun
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Wang, Keyun
dc.contributor.author
Siess, Don
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Burke, David
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Park, Byung S.
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Axthelm, Michael K
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Lewis, Anne
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Hirsch, Vanessa M.
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Graham, Barney S.
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Mascola, John R.
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Sacha, Jonah B.
dc.contributor.author
Haigwood, Nancy L.
dc.date.available
2018-05-07T21:29:01Z
dc.date.issued
2016-03
dc.identifier.citation
Hessell, Ann J.; Jaworski, Juan Pablo; Epson, Erin; Matsuda, Kenta; Pandey, Shilpi; et al.; Early short-term treatment with neutralizing human monoclonal antibodies halts SHIV infection in infant macaques; Nature Publishing Group; Nature Medicine; 22; 4; 3-2016; 362-368
dc.identifier.issn
1078-8956
dc.identifier.uri
http://hdl.handle.net/11336/44381
dc.description.abstract
Prevention of mother-to-child transmission (MTCT) of HIV remains a major objective where antenatal care is not readily accessible. We tested HIV-1–specific human neutralizing monoclonal antibodies (NmAbs) as a post-exposure therapy in an infant macaque model for intrapartum MTCT. One-month-old rhesus macaques were inoculated orally with the simian-human immunodeficiency virus SHIVSF162P3. On days 1, 4, 7 and 10 after virus exposure, we injected animals subcutaneously with NmAbs and quantified systemic distribution of NmAbs in multiple tissues within 24 h after antibody administration. Replicating virus was found in multiple tissues by day 1 in animals that were not treated. All NmAb-treated macaques were free of virus in blood and tissues at 6 months after exposure. We detected no anti-SHIV T cell responses in blood or tissues at necropsy, and no virus emerged after CD8+ T cell depletion. These results suggest that early passive immunotherapy can eliminate early viral foci and thereby prevent the establishment of viral reservoirs.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Nature Publishing Group
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Hiv
dc.subject
Anticuerpos Neutralizantes
dc.subject
Patogenia
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Transmision Perinatal
dc.subject.classification
Inmunología
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dc.subject.classification
Medicina Básica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Early short-term treatment with neutralizing human monoclonal antibodies halts SHIV infection in infant macaques
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-05-03T13:57:46Z
dc.journal.volume
22
dc.journal.number
4
dc.journal.pagination
362-368
dc.journal.pais
Reino Unido
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dc.journal.ciudad
Londres
dc.description.fil
Fil: Hessell, Ann J.. Oregon Health and Science University; Estados Unidos
dc.description.fil
Fil: Jaworski, Juan Pablo. Oregon Health and Science University; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Epson, Erin. Oregon Health and Science University; Estados Unidos
dc.description.fil
Fil: Matsuda, Kenta. National Institutes of Health; Estados Unidos
dc.description.fil
Fil: Pandey, Shilpi. Oregon Health and Science University; Estados Unidos
dc.description.fil
Fil: Kahl, Christoph. Oregon Health and Science University; Estados Unidos
dc.description.fil
Fil: Reed, Jason. Oregon Health and Science University; Estados Unidos
dc.description.fil
Fil: Sutton, William F.. Oregon Health and Science University; Estados Unidos
dc.description.fil
Fil: Hammond, Katherine B.. Oregon Health and Science University; Estados Unidos
dc.description.fil
Fil: Cheever, Tracy A.. Oregon Health and Science University; Estados Unidos
dc.description.fil
Fil: Barnette, Philip T.. Oregon Health and Science University; Estados Unidos
dc.description.fil
Fil: Legasse, Alfred W.. Oregon Health and Science University; Estados Unidos
dc.description.fil
Fil: Planer, Shannon. Oregon Health and Science University; Estados Unidos
dc.description.fil
Fil: Stanton, Jeffrey J.. Oregon Health and Science University; Estados Unidos
dc.description.fil
Fil: Pegu, Amarendra. National Institutes of Health; Estados Unidos
dc.description.fil
Fil: Chen, Xuejun. National Institutes of Health; Estados Unidos
dc.description.fil
Fil: Wang, Keyun. National Institutes of Health; Estados Unidos
dc.description.fil
Fil: Siess, Don. Oregon Health and Science University; Estados Unidos
dc.description.fil
Fil: Burke, David. Oregon Health and Science University; Estados Unidos
dc.description.fil
Fil: Park, Byung S.. Oregon Health and Science University; Estados Unidos
dc.description.fil
Fil: Axthelm, Michael K. Oregon Health and Science University; Estados Unidos
dc.description.fil
Fil: Lewis, Anne. Oregon Health and Science University; Estados Unidos
dc.description.fil
Fil: Hirsch, Vanessa M.. National Institutes of Health; Estados Unidos
dc.description.fil
Fil: Graham, Barney S.. National Institutes of Health; Estados Unidos
dc.description.fil
Fil: Mascola, John R.. National Institutes of Health; Estados Unidos
dc.description.fil
Fil: Sacha, Jonah B.. Oregon Health and Science University; Estados Unidos
dc.description.fil
Fil: Haigwood, Nancy L.. Oregon Health and Science University; Estados Unidos
dc.journal.title
Nature Medicine
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1038/nm.4063
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/nm.4063
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