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Artículo

Molecular understanding of cytokine -steroid hormones dialogue: Implications for human disease

Druker, Jimena PaolaIcon ; Liberman, Ana ClaraIcon ; Acuña, Matías; Giacomini, Damiana PaulaIcon ; Refojo, DamianIcon ; Silberstein Cuña, Susana IrisIcon ; Paez Pereda, Marcelo; Stalla, Günter K.; Holsboer, Florian; Arzt, Eduardo SimonIcon
Fecha de publicación: 12/2006
Editorial: Blackwell Publishing
Revista: Annals of the New York Academy of Sciences
ISSN: 0077-8923
e-ISSN: 1749-6632
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Otras Ciencias Médicas; Otras Ciencias Médicas

Resumen

Highly sophisticated mechanisms confer upon the immune system the capacity to respond with a certain degree of autonomy. However, the final outcome of an adaptative immune response depends on the interaction with other systems of the organism. The immune– neuroendocrine systems have an intimate cross-communication, making possible a satisfactory response to environmental changes. Part of this interaction occurs through cytokines and steroid hormones. The last step of this crosstalk is at the molecular level. In this article we will focus on the physical and functional interrelationship between cytokine signaling pathway–activated transcription factors (TFs) and steroid receptors in different cell models, where the signals triggered by cytokines and steroid hormones have major roles: (1) the ligand-dependent-activated glucocorticoid receptor (GR) influence the genetic program that specifies lineage commitment in T helper (Th) cell differentiation. How posttranslational modifications of several TFs as well as nuclear hormone receptors could be implicated in the molecular crosstalk between the immune–neuroendocrine messengers is discussed. (2) glucocorticoid (GC) antagonism on the TCR-induced T cell apoptosis. (3) estrogen receptor/TGF- family proteins molecular interaction implicated on pituitary prolactinomas pathogenesis. The functional crosstalk at the molecular level between immune and steroids signals is essential to determine an integrative response to both mediators (which in the last instance results in a new gene activation/repression profile) and constitutes the ultimate integrative level of interaction between the immune and neuroendocrine systems.
Palabras clave: Glucocorticoids , Camp , Tcr , Apoptosis , Gata-3 , T-Bet , Th1-Th2 Differentiation , Bmp-4 , Tgf-B , Prolactinoma , Estrogens
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/44181
URL: https://nyaspubs.onlinelibrary.wiley.com/doi/abs/10.1196/annals.1366.007
DOI: http://dx.doi.org/10.1196/annals.1366.007
Colecciones
Articulos(IBIOBA - MPSP)
Articulos de INST. D/INV.EN BIOMED.DE BS AS-CONICET-INST. PARTNER SOCIEDAD MAX PLANCK
Articulos(IFIBYNE)
Articulos de INST.DE FISIOL., BIOL.MOLECULAR Y NEUROCIENCIAS
Articulos(IIBBA)
Articulos de INST.DE INVEST.BIOQUIMICAS DE BS.AS(I)
Citación
Druker, Jimena Paola; Liberman, Ana Clara; Acuña, Matías; Giacomini, Damiana Paula; Refojo, Damian; et al.; Molecular understanding of cytokine -steroid hormones dialogue: Implications for human disease; Blackwell Publishing; Annals of the New York Academy of Sciences; 1088; 1; 12-2006; 297-306
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