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dc.contributor.author
Weibel, Mario Ignacio  
dc.contributor.author
Mengatto, Luciano Nicolas  
dc.contributor.author
Rintoul, Ignacio  
dc.contributor.author
Luna, Julio Alberto  
dc.date.available
2018-05-03T22:07:51Z  
dc.date.issued
2017-07  
dc.identifier.citation
Weibel, Mario Ignacio; Mengatto, Luciano Nicolas; Rintoul, Ignacio; Luna, Julio Alberto; Accurate prediction of shape and size of polyvinyl alcohol beads produced by extrusion dripping; Polymer Research Center Iran; Iranian Polymer Journal; 27; 3; 7-2017; 161-170  
dc.identifier.issn
1026-1265  
dc.identifier.uri
http://hdl.handle.net/11336/44094  
dc.description.abstract
Beads are one of the particulate delivery systems used to achieve protection and/or controlled delivery of different active ingredients or microorganisms. Polyvinyl alcohol is a non-toxic and biodegradable polymer and possesses extensive applications as a biomaterial. In the present work, two different strategies were applied for the prediction of shape and size of polyvinyl alcohol beads. These beads were obtained by extrusion dripping of a boric acid?polyvinyl alcohol aqueous solution into a basic aqueous gelling bath. The shapes and sizes of immature, mature and dry beads were determined using optical microscopy. Two different strategies included statistical and fluid dynamical (mechanistic) models to fit the experimental data. The shape of immature and mature beads was found to be dependent on the viscosity of the dripping solution for the former and the maturation time for the latter. The shape of dry beads was found to be mainly dependent on the particle contraction in the drying process. The size of mature and dried beads was correctly predicted from the operating conditions by means of a statistically developed model and from the dripping solution properties by means of a fluid dynamical approach. The optimal conditions for minimal dried bead size were calculated. The obtained mathematical models allow reduction in the amount of resources and time taken in the initial stages of the development of a novel encapsulated formulation. The mechanistic model may be applied to other polymeric systems once the corresponding parameters have been determined during proof-of-concept experiments.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Polymer Research Center Iran  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Beads · Extrusion Dripping ·  
dc.subject
Modelling   
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Polyvinyl Alcohol (Pva) ·  
dc.subject.classification
Otras Ciencias Químicas  
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Ciencias Químicas  
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CIENCIAS NATURALES Y EXACTAS  
dc.title
Accurate prediction of shape and size of polyvinyl alcohol beads produced by extrusion dripping  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2018-05-03T16:45:26Z  
dc.journal.volume
27  
dc.journal.number
3  
dc.journal.pagination
161-170  
dc.journal.pais
Irán  
dc.description.fil
Fil: Weibel, Mario Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina  
dc.description.fil
Fil: Mengatto, Luciano Nicolas. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina  
dc.description.fil
Fil: Rintoul, Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina  
dc.description.fil
Fil: Luna, Julio Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina  
dc.journal.title
Iranian Polymer Journal  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/s13726-017-0597-y