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dc.contributor.author
Farias, Ginny G.
dc.contributor.author
Valles, Ana Sofia
dc.contributor.author
Colombres, Marcela
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Godoy, Juan A.
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Toledo, Enrique M.
dc.contributor.author
Lukas, Ronald J.
dc.contributor.author
Barrantes, Francisco Jose
dc.contributor.author
Inestrosa, Nibaldo C.
dc.date.available
2018-05-02T18:50:26Z
dc.date.issued
2007-05-16
dc.identifier.citation
Farias, Ginny G.; Valles, Ana Sofia; Colombres, Marcela; Godoy, Juan A.; Toledo, Enrique M.; et al.; Wnt-7a Induces Presynaptic Colocalization of 7-Nicotinic Acetylcholine Receptors and Adenomatous Polyposis Coli in Hippocampal Neurons; Society for Neuroscience; Journal of Neuroscience; 27; 20; 16-5-2007; 5313-5325
dc.identifier.issn
0270-6474
dc.identifier.uri
http://hdl.handle.net/11336/43916
dc.description.abstract
Nicotinic acetylcholine receptors (nAChRs) contribute significantly to hippocampal function. Alpha7-nAChRs are present in presynaptic sites in hippocampal neurons and may influence transmitter release, but the factors that determine their presynaptic localization are unknown. We report here that Wnt-7a, a ligand active in the canonical Wnt signaling pathway, induces dissociation of the adenomatous polyposis coli (APC) protein from the beta-catenin cytoplasmic complex and the interaction of APC with alpha7-nAChRs in hippocampal neurons. Interestingly, Wnt-7a induces the relocalization of APC to membranes, clustering of APC in neurites, and coclustering of APC with different, presynaptic protein markers. Wnt-7a also increases the number and size of coclusters of alpha7-nAChRs and APC in presynaptic terminals. These short-term changes in alpha7-nAChRs occur in the few minutes after ligand exposure and involve translocation to the plasma membrane without affecting total receptor levels. Longer-term exposure to Wnt-7a increases nAChR alpha7 subunit levels in an APC-independent manner and increases clusters of alpha7-nAChRs in neurites via an APC-dependent process. Together, these results demonstrate that stimulation through the canonical Wnt pathway regulates the presynaptic localization of APC and alpha7-nAChRs with APC serving as an intermediary in the alpha7-nAChR relocalization process. Modulation by Wnt signaling may be essential for alpha7-nAChR expression and function in synapses.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Society for Neuroscience
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Nachr
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Apc
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Synapse
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Wnt Target Gene
dc.subject
Neurons
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Fisiología
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Wnt-7a Induces Presynaptic Colocalization of 7-Nicotinic Acetylcholine Receptors and Adenomatous Polyposis Coli in Hippocampal Neurons
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-04-16T13:36:19Z
dc.journal.volume
27
dc.journal.number
20
dc.journal.pagination
5313-5325
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Washington, D. C.
dc.description.fil
Fil: Farias, Ginny G.. Pontificia Universidad Católica de Chile; Chile
dc.description.fil
Fil: Valles, Ana Sofia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
dc.description.fil
Fil: Colombres, Marcela. Pontificia Universidad Católica de Chile; Chile
dc.description.fil
Fil: Godoy, Juan A.. Pontificia Universidad Católica de Chile; Chile
dc.description.fil
Fil: Toledo, Enrique M.. Pontificia Universidad Católica de Chile; Chile
dc.description.fil
Fil: Lukas, Ronald J.. Barrow Neurological Institute; Estados Unidos
dc.description.fil
Fil: Barrantes, Francisco Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
dc.description.fil
Fil: Inestrosa, Nibaldo C.. Pontificia Universidad Católica de Chile; Chile
dc.journal.title
Journal of Neuroscience
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.jneurosci.org/content/27/20/5313.long
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1523/JNEUROSCI.3934-06.2007
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