Artículo
The alkynylphosphonate analogue of calcitriol EM1 has potent anti-metastatic effects in breast cancer
Ferronato, María Julia; Obiol, Diego Javier
; Fermento, María Eugenia
; Gandini, Norberto Ariel
; Alonso, Eliana Noelia
; Salomón, Débora Gisele
; Vitale, Cristian Alejandro; Mascaro, Evangelina; Fall, Yagamare; Raimondi, Ana Rosa
; Curino, Alejandro Carlos
; Facchinetti, Maria Marta
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Fecha de publicación:
09/2015
Editorial:
Pergamon-elsevier Science Ltd
Revista:
Journal Of Steroid Biochemistry And Molecular Biology
ISSN:
0960-0760
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
The active form of vitamin D3, calcitriol, plays a major role in maintaining calcium/phosphate homeostasis. In addition, it is a potent antiproliferative and prodifferentiating agent. However, when effective antitumor doses of calcitriol are employed, hypercalcemic effects are observed, thus precluding its therapeutic application. To overcome this problem, structural analogues have been designed with the aim at retaining or even increasing the antitumor effects while decreasing its calcemic activity. This report shows the biological evaluation of an alkynylphosphonate vitamin D less-calcemic analogue in amurine model of breast cancer. We demonstrate that this compound has potent anti-metastatic effects through its action over cellular migration and invasion likely mediated through the up-regulation of Ecadherin expression. Based on the current in vitro and in vivo results, EM1 is a promising candidate as atherapeutic agent in breast cancer.
Palabras clave:
Breast Cancer
,
Analogue
,
Calcitriol
,
Vitamin D
,
Alkynylphosphonate
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(INIBIBB)
Articulos de INST.DE INVEST.BIOQUIMICAS BAHIA BLANCA (I)
Articulos de INST.DE INVEST.BIOQUIMICAS BAHIA BLANCA (I)
Articulos(OCA HOUSSAY)
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Citación
Ferronato, María Julia; Obiol, Diego Javier; Fermento, María Eugenia; Gandini, Norberto Ariel; Alonso, Eliana Noelia; et al.; The alkynylphosphonate analogue of calcitriol EM1 has potent anti-metastatic effects in breast cancer; Pergamon-elsevier Science Ltd; Journal Of Steroid Biochemistry And Molecular Biology; 154; 9-2015; 285-293
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