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Artículo

Development and assessment of a new cage-like particle adjuvant

Bertona, Daiana; Pujato, NazarenaIcon ; Bontempi, IvánIcon ; González, Verónica Doris GuadalupeIcon ; Cabrera, Gabriel GustavoIcon ; Gugliotta, Luis MarcelinoIcon ; Hozbor, Daniela FlaviaIcon ; Nicastro, AlcidesIcon ; Calvinho, Luis Fernando; Marcipar, Iván SergioIcon
Fecha de publicación: 10/2017
Editorial: Pharmaceutical Press-Royal Pharmaceutical Society Great Britian
Revista: Journal of Pharmacy and Pharmacology
ISSN: 0022-3573
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Nano-materiales; Nano-materiales

Resumen

Objectives: To obtain and assess stable cage-like particles with low surface charge density, which can be prepared using a standardized, economic and scalable method. Methods: To form these nanoparticles, the lipid composition and proportion as well the method were modified in relation to cage-like particles previously described elsewhere. Bovine albumin was used to compare ISPA performance with that of other adjuvants in mice and to assess stability. Adjuvant efficacy was analysed using a mouse model of Trypanosoma cruzi infection, which shows protection against an intracellular infection that needs a strong cellular response. Key findings: The new particles were better in terms of level, kinetics and profile of humoral responses than Freund Adjuvant, aluminium hydroxide and Montanide TM ISA 206; they also tended to improve ISCOMATRIX? performance. Particle size and adjuvant performance were conserved during the 6-month period assessed after preparation. In the model of Trypanosoma cruzi infection, mice immunized with ISPA and trans-sialidase developed high protection. Conclusions: The obtained nanoparticles were stable and outperformed the other assessed adjuvants in joining together the capacity of most adjuvants to enhance the immune response against specific antigen, to reduce the number of doses, to homogenize the response between individuals and to reach a balanced TH1/TH2 response.
Palabras clave: Adjuvant , Cage-Like Particle , Cellular Response , Humoral Response , Low Charge , Trypanosoma Cruzi
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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/43671
URL: http://doi.wiley.com/10.1111/jphp.12768
Colecciones
Articulos(IBBM)
Articulos de INST.DE BIOTECNOLOGIA Y BIOLOGIA MOLECULAR
Articulos(INTEC)
Articulos de INST.DE DES.TECNOL.PARA LA IND.QUIMICA (I)
Citación
Bertona, Daiana; Pujato, Nazarena; Bontempi, Iván; González, Verónica Doris Guadalupe; Cabrera, Gabriel Gustavo; et al.; Development and assessment of a new cage-like particle adjuvant; Pharmaceutical Press-Royal Pharmaceutical Society Great Britian; Journal of Pharmacy and Pharmacology; 69; 10; 10-2017; 1293-1303
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