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dc.contributor.author Bianchi, Carolina Paula
dc.contributor.author Meikle, A.
dc.contributor.author Benavente, Micaela Andrea
dc.contributor.author Álvarez, M.
dc.contributor.author Trasorras, Virginia Luz
dc.contributor.author Miragaya, Marcelo
dc.contributor.author Rodriguez, E.
dc.contributor.author Aba, Marcelo Alfredo
dc.date.available 2018-04-26T22:10:17Z
dc.date.issued 2015-12
dc.identifier.citation Bianchi, Carolina Paula; Meikle, A.; Benavente, Micaela Andrea; Álvarez, M.; Trasorras, Virginia Luz; et al.; Estrogen and Progesterone Receptors and COX-2 Expression in Endometrial Biopsy Samples During Maternal Recognition of Pregnancy in Llamas (Lama glama); Wiley Blackwell Publishing, Inc; Reproduction in Domestic Animals; 50; 6; 12-2015; 980-988
dc.identifier.issn 0936-6768
dc.identifier.uri http://hdl.handle.net/11336/43639
dc.description.abstract Endometrial expression of oestrogen receptor-a (ERa),progesterone receptor (PR) and cyclooxigenase-2 (COX-2)was evaluated in non-pregnant and pregnant llamas during theperiod when luteolysis/maternal recognition of pregnancy isexpected to occur. Females (n = 28) were divided into twogroups: non-pregnant llamas were induced to ovulate with aBuserelin injection, and endometrial biopsies were obtained onday 8 (n = 5) or 12 (n = 5) post-induction of ovulation.Animals of the pregnant group (n = 18) were mated with afertile male. Pregnancy was confirmed by the visualization ofthe embryo collected by transcervical flushing in 5 of 9 animalson day 8 post-mating and by progesterone profile on day 12post-mating in 4 of 9 animals, when endometrial biopsies wereobtained. An immunohistochemical technique was used toevaluate receptors population and COX-2 expression.Pregnant llamas showed a higher percentage of positive cellsand stronger intensity for ERa than for non-pregnant llamasin stroma on day 8 and in the luminal epithelium on day 12post-induction of ovulation, while a deep decrease in endometrialPR population was reported in pregnant llamas on thatday in luminal and glandular epithelia and stroma. In theluminal epithelium, COX-2 expression was lower in pregnantthan in non-pregnant animals. Briefly, the increase of ERa inpregnant llamas gives further support to the hypothesis thatoestrogens are involved in the mechanism of maternal recognitionof pregnancy. Endometrial PR decrease in pregnantllamas might be a necessary event to allow the expression ofproteins involved in conceptus attachment, a mechanismwidely accepted in other species. Moreover, embryo seems toattenuate maternal PGF2a secretion during early pregnancy bydecreasing the endometrial expression of COX-2 in the luminalepithelium of pregnant llamas.
dc.format application/pdf
dc.language.iso eng
dc.publisher Wiley Blackwell Publishing, Inc
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject ENDOMETRIUM
dc.subject RECEPTORS
dc.subject EARLY PREGNANCY
dc.subject LLAMAS
dc.subject.classification Otras Ciencias Veterinarias
dc.subject.classification Ciencias Veterinarias
dc.subject.classification CIENCIAS AGRÍCOLAS
dc.title Estrogen and Progesterone Receptors and COX-2 Expression in Endometrial Biopsy Samples During Maternal Recognition of Pregnancy in Llamas (Lama glama)
dc.type info:eu-repo/semantics/article
dc.type info:ar-repo/semantics/artículo
dc.type info:eu-repo/semantics/publishedVersion
dc.date.updated 2018-04-17T19:56:50Z
dc.journal.volume 50
dc.journal.number 6
dc.journal.pagination 980-988
dc.journal.pais Reino Unido
dc.journal.ciudad Londres
dc.description.fil Fil: Bianchi, Carolina Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
dc.description.fil Fil: Meikle, A.. Universidad del Uruguay; Uruguay
dc.description.fil Fil: Benavente, Micaela Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
dc.description.fil Fil: Álvarez, M.. Universidad Nacional del Centro de la Provincia de Buenos Aires.. Facultad de Ciencias Veterinarias. Departamento de Fisiopatologia. Laboratorio de Endocrinologia; Argentina
dc.description.fil Fil: Trasorras, Virginia Luz. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Instituto de Investigacion y Tecnología en Reproducción Animal; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil Fil: Miragaya, Marcelo. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Instituto de Investigacion y Tecnología en Reproducción Animal; Argentina
dc.description.fil Fil: Rodriguez, E.. Universidad Nacional del Centro de la Provincia de Buenos Aires.. Facultad de Ciencias Veterinarias. Departamento de Fisiopatologia. Laboratorio de Endocrinologia; Argentina
dc.description.fil Fil: Aba, Marcelo Alfredo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
dc.journal.title Reproduction in Domestic Animals
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/pdf/10.1111/rda.12618
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1111/rda.12618
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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)