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dc.contributor.author
Bianchi, Carolina Paula
dc.contributor.author
Meikle, A.
dc.contributor.author
Benavente, Micaela Andrea
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Álvarez, M.
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Trasorras, Virginia Luz
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Miragaya, Marcelo
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Rodriguez, E.
dc.contributor.author
Aba, Marcelo Alfredo
dc.date.available
2018-04-26T22:10:17Z
dc.date.issued
2015-12
dc.identifier.citation
Bianchi, Carolina Paula; Meikle, A.; Benavente, Micaela Andrea; Álvarez, M.; Trasorras, Virginia Luz; et al.; Estrogen and Progesterone Receptors and COX-2 Expression in Endometrial Biopsy Samples During Maternal Recognition of Pregnancy in Llamas (Lama glama); Wiley Blackwell Publishing, Inc; Reproduction in Domestic Animals; 50; 6; 12-2015; 980-988
dc.identifier.issn
0936-6768
dc.identifier.uri
http://hdl.handle.net/11336/43639
dc.description.abstract
Endometrial expression of oestrogen receptor-a (ERa),progesterone receptor (PR) and cyclooxigenase-2 (COX-2)was evaluated in non-pregnant and pregnant llamas during theperiod when luteolysis/maternal recognition of pregnancy isexpected to occur. Females (n = 28) were divided into twogroups: non-pregnant llamas were induced to ovulate with aBuserelin injection, and endometrial biopsies were obtained onday 8 (n = 5) or 12 (n = 5) post-induction of ovulation.Animals of the pregnant group (n = 18) were mated with afertile male. Pregnancy was confirmed by the visualization ofthe embryo collected by transcervical flushing in 5 of 9 animalson day 8 post-mating and by progesterone profile on day 12post-mating in 4 of 9 animals, when endometrial biopsies wereobtained. An immunohistochemical technique was used toevaluate receptors population and COX-2 expression.Pregnant llamas showed a higher percentage of positive cellsand stronger intensity for ERa than for non-pregnant llamasin stroma on day 8 and in the luminal epithelium on day 12post-induction of ovulation, while a deep decrease in endometrialPR population was reported in pregnant llamas on thatday in luminal and glandular epithelia and stroma. In theluminal epithelium, COX-2 expression was lower in pregnantthan in non-pregnant animals. Briefly, the increase of ERa inpregnant llamas gives further support to the hypothesis thatoestrogens are involved in the mechanism of maternal recognitionof pregnancy. Endometrial PR decrease in pregnantllamas might be a necessary event to allow the expression ofproteins involved in conceptus attachment, a mechanismwidely accepted in other species. Moreover, embryo seems toattenuate maternal PGF2a secretion during early pregnancy bydecreasing the endometrial expression of COX-2 in the luminalepithelium of pregnant llamas.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley Blackwell Publishing, Inc
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Endometrium
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Receptors
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Early Pregnancy
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Llamas
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Otras Ciencias Veterinarias
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Ciencias Veterinarias
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CIENCIAS AGRÍCOLAS
dc.title
Estrogen and Progesterone Receptors and COX-2 Expression in Endometrial Biopsy Samples During Maternal Recognition of Pregnancy in Llamas (Lama glama)
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-04-17T19:56:50Z
dc.journal.volume
50
dc.journal.number
6
dc.journal.pagination
980-988
dc.journal.pais
Reino Unido
dc.journal.ciudad
Londres
dc.description.fil
Fil: Bianchi, Carolina Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
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Fil: Meikle, A.. Universidad del Uruguay; Uruguay
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Fil: Benavente, Micaela Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
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Fil: Álvarez, M.. Universidad Nacional del Centro de la Provincia de Buenos Aires.. Facultad de Ciencias Veterinarias. Departamento de Fisiopatologia. Laboratorio de Endocrinologia; Argentina
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Fil: Trasorras, Virginia Luz. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Instituto de Investigacion y Tecnología en Reproducción Animal; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
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Fil: Miragaya, Marcelo. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Instituto de Investigacion y Tecnología en Reproducción Animal; Argentina
dc.description.fil
Fil: Rodriguez, E.. Universidad Nacional del Centro de la Provincia de Buenos Aires.. Facultad de Ciencias Veterinarias. Departamento de Fisiopatologia. Laboratorio de Endocrinologia; Argentina
dc.description.fil
Fil: Aba, Marcelo Alfredo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
dc.journal.title
Reproduction in Domestic Animals
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/pdf/10.1111/rda.12618
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1111/rda.12618
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