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dc.contributor.author
Kalback, Walter
dc.contributor.author
Esh, Chera
dc.contributor.author
Castaño, Eduardo Miguel
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dc.contributor.author
Rahman, Afroza
dc.contributor.author
Kokjohn, Tyler
dc.contributor.author
Luehrs, Dean C.
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Sue, Lucia
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Cisneros, Raquel
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Gerber, Francoise
dc.contributor.author
Richardson, Claudia
dc.contributor.author
Bohrmann, Bernd
dc.contributor.author
Walker, Douglas G.
dc.contributor.author
Beach, Thomas G.
dc.contributor.author
Roher, Alex E.
dc.date.available
2018-04-26T18:26:44Z
dc.date.issued
2004-07
dc.identifier.citation
Kalback, Walter; Esh, Chera; Castaño, Eduardo Miguel; Rahman, Afroza; Kokjohn, Tyler; et al.; Atherosclerosis, vascular amyloidosis and brain hypoperfusion in the pathogenesis of sporadic Alzheimer's disease; Maney Publishing; Neurological Research; 26; 5; 7-2004; 525-539
dc.identifier.issn
0161-6412
dc.identifier.uri
http://hdl.handle.net/11336/43568
dc.description.abstract
We postulate that severe atherosclerotic occlusion of the circle of Willis and leptomeningeal arteries is an important factor in the pathogenesis of some sporadic Alzheimer's disease (AD) cases. These arterial stenoses are complicated by an overwhelming amyloid accumulation in the walls of leptomeningeal and cortical arteries resulting in a significant decrease in perfusion pressure and consequent ischemia/hypoxia of the brain tissue. We also propose that the distal areas of the white matter (WM) will be the first affected by a lack of oxygen and nutrients. Our hypotheses are supported by the following observations: (1) the number of stenoses is more frequent in AD than in the control population (p = 0.008); (2) the average index of occlusion is greater in AD than in the control group (p < 0.00001); (3) the index of stenosis and the total number of stenoses per case are positively correlated (R = 0.67); (4) the index of stenosis correlates with the neuropathological lesions of AD and with the MMSE psychometric test; (5) the number and degree of atherosclerosis of the anterior, middle and posterior cerebral arteries is more severe in cases of AD than in the control population; (6) atherosclerosis severity is apparently associated with the severity of the vascular amyloidosis; (7) the WM rarefaction correlates with the severity of the atherosclerosis and vascular amyloidosis; (8) the total cell count and microvessel count in the areas of WM rarefaction correlate with the neuropathological lesions of AD and with the MMSE score. Our data strongly suggest that severe hemodynamic disturbances contribute to sporadic AD and support the numerous observations indicating cardiovascular system participation in the pathogenesis of these dementias.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Maney Publishing
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Alzheimer'S Disease
dc.subject
Atherosclerosis
dc.subject
Vascular Amyloidosis
dc.subject.classification
Otras Ciencias Biológicas
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Atherosclerosis, vascular amyloidosis and brain hypoperfusion in the pathogenesis of sporadic Alzheimer's disease
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-04-10T13:38:57Z
dc.identifier.eissn
1743-1328
dc.journal.volume
26
dc.journal.number
5
dc.journal.pagination
525-539
dc.journal.pais
Reino Unido
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dc.journal.ciudad
London
dc.description.fil
Fil: Kalback, Walter. Sun Health Research Institute; Estados Unidos
dc.description.fil
Fil: Esh, Chera. Sun Health Research Institute; Estados Unidos
dc.description.fil
Fil: Castaño, Eduardo Miguel. Sun Health Research Institute; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
dc.description.fil
Fil: Rahman, Afroza. Sun Health Research Institute; Estados Unidos
dc.description.fil
Fil: Kokjohn, Tyler. Midwestern University; Estados Unidos
dc.description.fil
Fil: Luehrs, Dean C.. Sun Health Research Institute; Estados Unidos
dc.description.fil
Fil: Sue, Lucia. Sun Health Research Institute; Estados Unidos
dc.description.fil
Fil: Cisneros, Raquel. Sun Health Research Institute; Estados Unidos
dc.description.fil
Fil: Gerber, Francoise. La Roche Ltd.; Suiza
dc.description.fil
Fil: Richardson, Claudia. La Roche Ltd.; Suiza
dc.description.fil
Fil: Bohrmann, Bernd. La Roche Ltd.; Suiza
dc.description.fil
Fil: Walker, Douglas G.. Sun Health Research Institute; Estados Unidos
dc.description.fil
Fil: Beach, Thomas G.. Sun Health Research Institute; Estados Unidos
dc.description.fil
Fil: Roher, Alex E.. Sun Health Research Institute; Estados Unidos
dc.journal.title
Neurological Research
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/abs/10.1179/016164104225017668
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1179/016164104225017668
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