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dc.contributor.author
Mantegazza, Adriana Rita
dc.contributor.author
Barrio, Maria Marcela
dc.contributor.author
Moutel, Sandrine
dc.contributor.author
Bover, Laura
dc.contributor.author
Weck, Markus
dc.contributor.author
Brossart, Peter
dc.contributor.author
Teillaud, Jean Luc
dc.contributor.author
Mordoh, Jose
dc.date.available
2018-04-25T18:58:34Z
dc.date.issued
2004-04
dc.identifier.citation
Mantegazza, Adriana Rita; Barrio, Maria Marcela; Moutel, Sandrine; Bover, Laura; Weck, Markus; et al.; CD63 tetraspanin slows down cell migration and translocates to the endosomal-lysosomal-MIICs route after extracellular stimuli in human immature dendritic cells; American Society of Hematology; Blood; 104; 4; 4-2004; 1183-1190
dc.identifier.issn
0006-4971
dc.identifier.uri
http://hdl.handle.net/11336/43490
dc.description.abstract
We analyzed herein whether members of the tetraspanin superfamily are involved in human immature dendritic cell (DC) functions such as foreign antigen internalization, phagocytosis, and cell migration. We show that CD63, CD9, CD81, CD82, and CD151 are present in immature DCs. Whereas CD9 and CD81 are mostly expressed at the cell surface, CD63 and CD82 are also located in intracellular organelles. Complexes of monoclonal antibody (Mab) FC-5.01-CD63 or Fab-5.01-CD63 were rapidly translocated "outside-in" and followed the endocytic pathway through early endosomes and lysosomes, reaching major histocompatibility complex (MHC) class II-enriched compartments (MIICs) in less than one hour. Internalization of CD63 was also observed during Saccharomyces cerevisiae phagocytosis. Moreover, an association of CD63 with the beta-glycan receptor dectin-1 was observed. Mabs against CD9, CD63, CD81, and CD82 enhanced by 50% the migration induced by the chemokines macrophage inflammatory protein-5 (MIP-5) and MIP-1alpha. Concomitantly, Mabs against CD63 and CD82 diminished the surface expression of CD29, CD11b, CD18, and alpha5 integrins. By immunoprecipitation experiments we found that CD63 associated with integrins CD11b and CD18. These results suggest that CD9, CD63, CD81, and CD82 could play a role in modulating the interactions between immature DCs and their environment, slowing their migratory ability. However, only CD63 would intervene in the internalization of complex antigens.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
American Society of Hematology
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Dendritic Cells
dc.subject
Monoclonal Antibodies
dc.subject.classification
Otras Ciencias Biológicas
dc.subject.classification
Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
CD63 tetraspanin slows down cell migration and translocates to the endosomal-lysosomal-MIICs route after extracellular stimuli in human immature dendritic cells
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-04-10T13:40:56Z
dc.identifier.eissn
1528-0020
dc.journal.volume
104
dc.journal.number
4
dc.journal.pagination
1183-1190
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Washington
dc.description.fil
Fil: Mantegazza, Adriana Rita. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
dc.description.fil
Fil: Barrio, Maria Marcela. Fundación Cáncer. Centro de Investigaciones Oncológicas; Argentina
dc.description.fil
Fil: Moutel, Sandrine. Inserm; Francia
dc.description.fil
Fil: Bover, Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina. Fundación Cáncer. Centro de Investigaciones Oncológicas; Argentina
dc.description.fil
Fil: Weck, Markus. University of Tübingen; Alemania
dc.description.fil
Fil: Brossart, Peter. Inserm; Francia
dc.description.fil
Fil: Teillaud, Jean Luc. Inserm; Francia
dc.description.fil
Fil: Mordoh, Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina. Fundación Cáncer. Centro de Investigaciones Oncológicas; Argentina
dc.journal.title
Blood
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.bloodjournal.org/content/104/4/1183.long
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1182/blood-2004-01-0104
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