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dc.contributor.author
Serrano Sponton, Lucas Ezequiel  
dc.contributor.author
Soria, Gonzalo Jose  
dc.contributor.author
Dubroqua, Sylvain  
dc.contributor.author
Singer, Philipp  
dc.contributor.author
Feldon, Joram  
dc.contributor.author
Gargiulo, Pascual Angel  
dc.contributor.author
Yee, Benjamin K.  
dc.date.available
2018-04-24T20:28:55Z  
dc.date.issued
2017-11  
dc.identifier.citation
Serrano Sponton, Lucas Ezequiel; Soria, Gonzalo Jose; Dubroqua, Sylvain; Singer, Philipp; Feldon, Joram; et al.; Negative transfer effects between reference memory and working memory training in the water maze in C57BL/6 mice; Elsevier Science; Behavioural Brain Research; 339; 11-2017; 268-296  
dc.identifier.issn
0166-4328  
dc.identifier.uri
http://hdl.handle.net/11336/43365  
dc.description.abstract
The water maze is one of the most widely employed spatial learning paradigms in the cognitive profiling of genetically modified mice. Oftentimes, tests of reference memory (RM) and working memory (WM) in the water maze are sequentially evaluated in the same animals. However, critical difference in the rules governing efficient escape from the water between WM and RM tests is expected to promote the adoption of incompatible mnemonic or navigational strategies. Hence, performance in a given test is likely poorer if it follows the other test instead of being conducted first. Yet, the presence of such negative transfer effects (or proactive interference) between WM and RM training in the water maze is often overlooked in the literature. To gauge whether this constitutes a serious concern, the present study determined empirically the magnitude, persistence, and directionality of the transfer effect in wild-type C57BL/6 mice. We contrasted the order of tests between two cohorts of mice. Performance between the two cohorts in the WM and RM tests were then separately compared. We showed that prior training of either test significantly reduced performance in the subsequent one. The statistical effect sizes in both directions were moderate to large. Although extended training could overcome the deficit, it could re-emerge later albeit in a more transient fashion. Whenever RM and WM water maze tests are conducted sequentially in the same animals – regardless of the test order, extra caution is necessary when interpreting the outcomes in the second test. Counterbalancing test orders between animals is recommended.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Elsevier Science  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Mouse  
dc.subject
Spatial Learning  
dc.subject
Transfer Effect  
dc.subject
Water Maze  
dc.subject.classification
Inmunología  
dc.subject.classification
Medicina Básica  
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
Negative transfer effects between reference memory and working memory training in the water maze in C57BL/6 mice  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2018-04-16T13:46:57Z  
dc.journal.volume
339  
dc.journal.pagination
268-296  
dc.journal.pais
Países Bajos  
dc.journal.ciudad
Amsterdam  
dc.description.fil
Fil: Serrano Sponton, Lucas Ezequiel. Mainz University Hospital. Department of Neurosurger; Alemania. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza; Argentina  
dc.description.fil
Fil: Soria, Gonzalo Jose. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza; Argentina  
dc.description.fil
Fil: Dubroqua, Sylvain. Institute of Brain and Cognitive Science; China. Laboratory of Behavioural Neurobiology; Suiza  
dc.description.fil
Fil: Singer, Philipp. Institute of Brain and Cognitive Science; China. Roche Diagnostics; Suiza  
dc.description.fil
Fil: Feldon, Joram. Laboratory of Behavioural Neurobiology; Suiza. Roche Diagnostics; Suiza  
dc.description.fil
Fil: Gargiulo, Pascual Angel. Universidad Nacional de cuyo. Facultad de Ciencias Médicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza; Argentina  
dc.description.fil
Fil: Yee, Benjamin K.. Laboratory of Behavioural Neurobiology; Suiza. The Hong Kong Polytechnic University. Faculty of Health and Social Sciences,; China  
dc.journal.title
Behavioural Brain Research  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.bbr.2017.10.033  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0166432817312081