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dc.contributor.author
Roco, Julieta  
dc.contributor.author
Alarcón, Gabriela del Jesús  
dc.contributor.author
Sierra, Liliana Beatríz  
dc.contributor.author
Zampini, Iris Catiana  
dc.contributor.author
Isla, Maria Ines  
dc.contributor.author
Jerez, Susana Josefina  
dc.date.available
2018-04-24T20:24:46Z  
dc.date.issued
2017-06  
dc.identifier.citation
Roco, Julieta; Alarcón, Gabriela del Jesús; Sierra, Liliana Beatríz; Zampini, Iris Catiana; Isla, Maria Ines; et al.; Beneficial effects of hydroalcoholic extract and flavonoids from Zuccagnia punctata in a rabbit model of vascular dysfunction induced by high cholesterol diet; Birkhauser Boston Inc; Medicinal Chemistry Research; 26; 10; 6-2017; 2336-2344  
dc.identifier.issn
1054-2523  
dc.identifier.uri
http://hdl.handle.net/11336/43360  
dc.description.abstract
Abstract This study evaluated the effects of a Zuccagniapunctata standardized hydroalcoholic extract (ZpE) and threeof its major flavonoids [2′,4′-dihydroxychalcone (DHC), 7-hydroxyflavanone (HF) and 3,7-dihydroxyflavone (DHF)] onthe vascular reactivity of aortic rings with endothelial dysfunctioninduced by feeding rabbits on a high cholesteroldiet. Rabbits were fed with either normal chow or a dietcontaining 1% cholesterol for 5?6 weeks. Isometric contractionswere measured. Concentration response curves to ZpE(range from 4×10−2 to 4 ×10 μg gallic acid equivalent/ml),DHC, DHF or HF (range from 10−9 to 10−4 M) showedconcentration-dependent relaxation of arteries pre-contractedwith phenylephrine. ZpE (4×10−2, 4 ×10−1 and 4 μg gallicacid equivalent/ml), HF (10−9, 10−7, 10−5 M), DHC (10−9M) and DHF (10−9 M) added to the bath improved acetylcholineaffinity. Pre-treatment of arteries with ZpE (4×10−2 μg gallic acid equivalent/ml) and DHC (10−9 M)reduced phenylephrine-induced contraction. Incubationwith the higher dose of ZpE (4 μg gallic acid equivalent/ml)reduced the angiotensin II-maximal contraction (Cmax) actingas a non-competitive antagonist, while DHC and DHF(10−5 M) caused a non-parallel rightward of the angiotensinII-concentration response curves and reduced the Cmaxacting as mixed antagonists. ZpE (4 × 10−2 μg gallic acidequivalent/ml), DHC and DHF (10−9 M) caused a rightwarddisplacement of angiotensin II-concentration responsecurves acting as competitive antagonists. In conclusion, thepresent study demonstrated that a ZpE and its major flavonoidshad beneficial effects in arteries with vasculardysfunction induced by hypercholesterolemia. Therefore itsuse as herbal medicine to prevent cardiovascular risks factorsmay be promising.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Birkhauser Boston Inc  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Zuccagnia Punctata  
dc.subject
Vascular Reactivity  
dc.subject
Endothelial Dysfunction  
dc.subject.classification
Otras Ciencias Biológicas  
dc.subject.classification
Ciencias Biológicas  
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CIENCIAS NATURALES Y EXACTAS  
dc.title
Beneficial effects of hydroalcoholic extract and flavonoids from Zuccagnia punctata in a rabbit model of vascular dysfunction induced by high cholesterol diet  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2018-04-23T19:54:43Z  
dc.journal.volume
26  
dc.journal.number
10  
dc.journal.pagination
2336-2344  
dc.journal.pais
Estados Unidos  
dc.journal.ciudad
Boston  
dc.description.fil
Fil: Roco, Julieta. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina  
dc.description.fil
Fil: Alarcón, Gabriela del Jesús. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina  
dc.description.fil
Fil: Sierra, Liliana Beatríz. Universidad Nacional de Tucumán. Facultad de Ciencias Naturales e Instituto Miguel Lillo; Argentina  
dc.description.fil
Fil: Zampini, Iris Catiana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán; Argentina. Universidad Nacional de Tucumán. Facultad de Ciencias Naturales e Instituto Miguel Lillo; Argentina  
dc.description.fil
Fil: Isla, Maria Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán; Argentina. Universidad Nacional de Tucumán. Facultad de Ciencias Naturales e Instituto Miguel Lillo; Argentina  
dc.description.fil
Fil: Jerez, Susana Josefina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina. Universidad Nacional de Tucumán. Facultad de Ciencias Naturales e Instituto Miguel Lillo; Argentina  
dc.journal.title
Medicinal Chemistry Research  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/10.1007/s00044-017-1934-6  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1007/s00044-017-1934-6