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Artículo

Effect of Zuccagnia punctata Cav. (Fabaceae) extract on pro-inflammatory enzymes and on planktonic cells and biofilm from Staphylococcus aureus: Toxicity studies

Nuño, GabrielaIcon ; Alberto, Maria RosaIcon ; Arena, Mario EduardoIcon ; Zampini, Iris CatianaIcon ; Isla, Maria InesIcon
Fecha de publicación: 10/2016
Editorial: Elsevier
Revista: Saudi Journal of Biological Sciences
ISSN: 1319-562X
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Otras Ciencias Biológicas

Resumen

Zuccagnia punctata Cav. (Fabaceae), a native plant from Argentina has been used traditionally as medicinal species. The aim of the study was to validate the antibiotic and anti-inflammatory potential of Z. punctata organic extract (ZpE) and the major compounds; 2´,4´-dihydroxy-3´-methoxychalcone (DHMC), 2´,4´-dihydroxychalcone (DHC), 7-hydroxyflavanone (7-HF) and 3,7-dihydroxyflavone (DHF); using an in vitro model. The antibiotic activity was determined using a broth microdilution method and the minimum inhibitory concentration (MIC) was determined. The extract and the isolation compounds affect the normal growth of all assayed Staphylococcus aureus strains. The MIC values for ZpE and isolated compounds were between 125 and 500μg/mL and between 25 and 400μg/mL, respectively, against all assayed strains. The inhibitory effect of extract and isolated compounds on biofilm formation and on pro-inflammatory enzymes (sPLA2, COX-2, LOX) was analyzed. The compound DHC was the most active on sPLA2 while DHF and DHMC showed the highest activity on LOX. Both the extract and pure compounds except DHMC were active against COX-2. It can be concluded that the phytocomplex and the pure compounds possessed antibiotic and anti-inflammatory activities under the conditions tested, and could be a good alternative therapy for infective and inflammatory processes.
Palabras clave: Anti-Inflammatory , Bioactive Metabolite , Biofilm Formation , Staphylococcus Aureus , Zuccagnia Punctata
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Atribución-NoComercial-SinDerivadas 2.5 Argentina (CC BY-NC-ND 2.5 AR)
Identificadores
URI: http://hdl.handle.net/11336/43317
DOI: https://dx.doi.org/10.1016/j.sjbs.2016.10.014
URL: https://www.sciencedirect.com/science/article/pii/S1319562X16301383
Colecciones
Articulos(INQUINOA)
Articulos de INST.DE QUIMICA DEL NOROESTE
Citación
Nuño, Gabriela; Alberto, Maria Rosa; Arena, Mario Eduardo; Zampini, Iris Catiana; Isla, Maria Ines; Effect of Zuccagnia punctata Cav. (Fabaceae) extract on pro-inflammatory enzymes and on planktonic cells and biofilm from Staphylococcus aureus: Toxicity studies; Elsevier; Saudi Journal of Biological Sciences; 10-2016
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