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dc.contributor.author
Morrison, Christopher D.
dc.contributor.author
Pistell, Paul J.
dc.contributor.author
Ingram, Donald K.
dc.contributor.author
Johnson, William D.
dc.contributor.author
Liu, Ying
dc.contributor.author
Fernandez Kim, Sun Ok
dc.contributor.author
White, Christy L.
dc.contributor.author
Purpera, Megan N.
dc.contributor.author
Uranga, Romina Maria
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dc.contributor.author
Bruce Keller, Annadora J.
dc.contributor.author
Keller, Jeffrey N.
dc.date.available
2018-04-24T17:51:59Z
dc.date.issued
2010-09
dc.identifier.citation
Morrison, Christopher D.; Pistell, Paul J.; Ingram, Donald K.; Johnson, William D.; Liu, Ying; et al.; High fat diet increases hippocampal oxidative stress and cognitive impairment in aged mice: implications for decreased Nrf2 signaling; Wiley Blackwell Publishing, Inc; Journal of Neurochemistry; 114; 6; 9-2010; 1581-1589
dc.identifier.issn
0022-3042
dc.identifier.uri
http://hdl.handle.net/11336/43269
dc.description.abstract
Long term consumption of a high fat diet (HFD) contributes to increased morbidity and mortality. Yet the specific effects of HFD consumption on brain aging are poorly understood. In the present study 20-month old male C57Bl/6 mice were fed either “Western Diet” (WD, 41% fat), very high fat lard diet (HFL, 60% fat), or corresponding control diets for 16 weeks and then assessed for changes in metabolism and brain homeostasis. Although both HFDs increased adiposity and fasting blood glucose, only the HFL diet increased age-related oxidative damage (protein carbonyls) and impaired retention in the behavioral test. This selective increase in oxidative damage and cognitive decline was also associated with a decline in Nrf2 levels and Nrf2 activity, suggesting a potential role for decreased antioxidant response. Taken together, these data suggest that while adiposity and insulin resistance following HFD consumption are linked to increased morbidity, the relationship between these factors and brain homeostasis during aging is not a linear relationship. More specifically, these data implicate impaired Nrf2 signaling and increased cerebral oxidative stress as mechanisms underlying HFD-induced declines in cognitive performance in the aged brain.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley Blackwell Publishing, Inc
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
Oxidatie Stress
dc.subject
Aging
dc.subject
Cognition
dc.subject
High-Fat Diet
dc.subject.classification
Otras Ciencias Biológicas
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
High fat diet increases hippocampal oxidative stress and cognitive impairment in aged mice: implications for decreased Nrf2 signaling
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-04-12T14:25:08Z
dc.journal.volume
114
dc.journal.number
6
dc.journal.pagination
1581-1589
dc.journal.pais
Reino Unido
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dc.journal.ciudad
Londres
dc.description.fil
Fil: Morrison, Christopher D.. Pennington Biomedical Research Center; Estados Unidos
dc.description.fil
Fil: Pistell, Paul J.. Pennington Biomedical Research Center; Estados Unidos
dc.description.fil
Fil: Ingram, Donald K.. Pennington Biomedical Research Center; Estados Unidos
dc.description.fil
Fil: Johnson, William D.. Pennington Biomedical Research Center; Estados Unidos
dc.description.fil
Fil: Liu, Ying. Pennington Biomedical Research Center; Estados Unidos
dc.description.fil
Fil: Fernandez Kim, Sun Ok. Pennington Biomedical Research Center; Estados Unidos
dc.description.fil
Fil: White, Christy L.. Pennington Biomedical Research Center; Estados Unidos
dc.description.fil
Fil: Purpera, Megan N.. Pennington Biomedical Research Center; Estados Unidos
dc.description.fil
Fil: Uranga, Romina Maria. Pennington Biomedical Research Center; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
dc.description.fil
Fil: Bruce Keller, Annadora J.. Pennington Biomedical Research Center; Estados Unidos
dc.description.fil
Fil: Keller, Jeffrey N.. Pennington Biomedical Research Center; Estados Unidos
dc.journal.title
Journal of Neurochemistry
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2945419/
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1111/j.1471-4159.2010.06865.x
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1471-4159.2010.06865.x
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