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dc.contributor.author
Gutierrez, Leandro German
dc.contributor.author
Noriega, Maria Fernanda
dc.contributor.author
Laudicina, Alejandro
dc.contributor.author
Quatrin, Mariana
dc.contributor.author
Bengió, Raquel María
dc.contributor.author
Larripa, Irene Beatriz
dc.date.available
2018-04-24T17:50:15Z
dc.date.issued
2017-05
dc.identifier.citation
Gutierrez, Leandro German; Noriega, Maria Fernanda; Laudicina, Alejandro; Quatrin, Mariana; Bengió, Raquel María; et al.; An unusual translocation, t(1;11)(q21;q23), in a case of chronic myeloid leukemia with a cryptic Philadelphia chromosome; Spandidos Publication; Oncology Letters; 13; 5; 5-2017; 3159-3162
dc.identifier.issn
1792-1082
dc.identifier.uri
http://hdl.handle.net/11336/43267
dc.description.abstract
Chronic myeloid leukemia is characterized by the translocation t(9;22)(q34;q11) (Philadelphia chromosome). Although it is not frequent, additional chromosome abnormalities can be detected at diagnosis and some of them have been associated with adverse cytogenetic and molecular outcome. We report a case of Chronic myeloid leukemia presenting the translocation t(1;11)(q21;q23) and a cryptic Philadelphia chromosome. The presence of additional chromosome abnormalities could generate greater genetic instability, promoting the emergence of further alterations. Our findings suggest that t(1;11)(q21;q23) avoided good response to tyrosine kinase inhibitors therapy. The patient evolves with primary resistance and subsequently at the recent control the T315I mutation was detected.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Spandidos Publication
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Lmc
dc.subject
Cromosoma Ph Criptico
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T(1;11)
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Aca
dc.subject.classification
Medicina Critica y de Emergencia
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Medicina Clínica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
An unusual translocation, t(1;11)(q21;q23), in a case of chronic myeloid leukemia with a cryptic Philadelphia chromosome
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-04-16T14:28:20Z
dc.journal.volume
13
dc.journal.number
5
dc.journal.pagination
3159-3162
dc.journal.pais
Reino Unido
dc.journal.ciudad
Londres
dc.description.fil
Fil: Gutierrez, Leandro German. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
dc.description.fil
Fil: Noriega, Maria Fernanda. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas "Mariano R. Castex"; Argentina
dc.description.fil
Fil: Laudicina, Alejandro. Lexel SRL; Argentina
dc.description.fil
Fil: Quatrin, Mariana. Provincia de Buenos Aires. Ministerio de Salud. Hospital de Niños "Sor María Ludovica" de la Plata; Argentina
dc.description.fil
Fil: Bengió, Raquel María. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas "Mariano R. Castex"; Argentina
dc.description.fil
Fil: Larripa, Irene Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
dc.journal.title
Oncology Letters
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3892/ol.2017.5845
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.spandidos-publications.com/10.3892/ol.2017.5845


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