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dc.contributor.author
Rozenblum, Tomas Guido
dc.contributor.author
Lopez, Vanina Gisela
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Vitullo, Alfredo Daniel
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Radrizzani Helguera, Martin
dc.date.available
2018-04-24T17:35:25Z
dc.date.issued
2015-12
dc.identifier.citation
Rozenblum, Tomas Guido; Lopez, Vanina Gisela; Vitullo, Alfredo Daniel; Radrizzani Helguera, Martin; Aptamers: current challenges and future prospects; Informa Healthcare; Expert Opinion On Drug Discovery; 11; 2; 12-2015; 127-135
dc.identifier.issn
1746-0441
dc.identifier.uri
http://hdl.handle.net/11336/43257
dc.description.abstract
Introduction: Aptamers are oligonucleotide molecules raised in vitro from large combinatorial libraries of nucleic acids and developed to bind to targets with high affinity and specificity. Whereas novel target molecules are proposed for therapeutic intervention and diagnostic, aptamer technology has a great potential to become a source of lead compounds.Areas Covered: In this review the authors address the current status of the technology and highlight the recent progress in aptamer-based technologies. They also discuss the current major technical limitations of aptamer technology and propose original solutions based on existing technologies that could result in a solid aptamer-discovery platform.Expert opinion: Whereas aptamers have shown to bind to targets with similar affinities and specificities to those of antibodies, aptamers have several advantages that could outweigh antibody technology and open new opportunities for better medical and diagnostic solutions. However, the current status of the aptamer technology suffers from several technical limitations that slowdown the progression of novel aptamers into the clinic and makes the business around aptamers challenging.
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application/pdf
dc.language.iso
eng
dc.publisher
Informa Healthcare
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Aptamer
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Biosensors
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Lead Discovery
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Dna Array
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Otras Biotecnologías de la Salud
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Biotecnología de la Salud
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Aptamers: current challenges and future prospects
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-04-17T13:49:07Z
dc.journal.volume
11
dc.journal.number
2
dc.journal.pagination
127-135
dc.journal.pais
Reino Unido
dc.journal.ciudad
Londres
dc.description.fil
Fil: Rozenblum, Tomas Guido. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Maimónides; Argentina
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Fil: Lopez, Vanina Gisela. Universidad Maimónides; Argentina
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Fil: Vitullo, Alfredo Daniel. Universidad Maimónides; Argentina
dc.description.fil
Fil: Radrizzani Helguera, Martin. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de San Martín; Argentina
dc.journal.title
Expert Opinion On Drug Discovery
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1517/17460441.2016.1126244
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/full/10.1517/17460441.2016.1126244
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