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dc.contributor.author
Chernajovsky, Yuti
dc.contributor.author
Gould, David J.
dc.contributor.author
Podhajcer, Osvaldo Luis
dc.date.available
2018-04-23T18:07:22Z
dc.date.issued
2004-10
dc.identifier.citation
Chernajovsky, Yuti; Gould, David J.; Podhajcer, Osvaldo Luis; Gene therapy for autoimmune diseases: quo vadis?; Nature Publishing Group; Nature Reviews Immunology; 4; 10; 10-2004; 800-811
dc.identifier.issn
1474-1733
dc.identifier.uri
http://hdl.handle.net/11336/43066
dc.description.abstract
Biological therapies using antibodies and cytokines are becoming widespread for the treatment of chronic inflammatory autoimmune diseases. However, these treatments have several limitations - such as expense, the need for repeated injections and unwanted side-effects - that can be overcome by genetic delivery. This review summarizes the ingenuity, sophistication and variety of gene-therapy approaches that have been taken in the design of therapeutic molecules and vectors, the engineering of cells and the regulation of gene expression for the targeting of disease outcome. We focus our attention on multiple sclerosis, type 1 diabetes and rheumatoid arthritis.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Nature Publishing Group
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Gene
dc.subject
Therapy
dc.subject
Cancer
dc.subject
Autoimmunity
dc.subject.classification
Otras Ciencias Biológicas
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Gene therapy for autoimmune diseases: quo vadis?
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-04-10T13:42:33Z
dc.journal.volume
4
dc.journal.number
10
dc.journal.pagination
800-811
dc.journal.pais
Reino Unido
dc.journal.ciudad
Londres
dc.description.fil
Fil: Chernajovsky, Yuti. University of London; Reino Unido
dc.description.fil
Fil: Gould, David J.. University of London; Reino Unido
dc.description.fil
Fil: Podhajcer, Osvaldo Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
dc.journal.title
Nature Reviews Immunology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/nri1459
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1038/nri1459
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