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dc.contributor.author
Griffin, Julian L.
dc.contributor.author
Anthony, Daniel C.
dc.contributor.author
Campbell, Sandra J.
dc.contributor.author
Gauldie, Jack
dc.contributor.author
Pitossi, Fernando Juan
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dc.contributor.author
Styles, Peter
dc.contributor.author
Sibson, Nicola R.
dc.date.available
2018-04-23T15:53:49Z
dc.date.issued
2004-06
dc.identifier.citation
Griffin, Julian L.; Anthony, Daniel C.; Campbell, Sandra J.; Gauldie, Jack; Pitossi, Fernando Juan; et al.; Study of cytokine induced neuropathology by high resolution proton NMR spectroscopy of rat urine; Elsevier Science; FEBS Letters; 568; 1-3; 6-2004; 49-54
dc.identifier.issn
0014-5793
dc.identifier.uri
http://hdl.handle.net/11336/43019
dc.description.abstract
Multiple sclerosis is a major cause of non-traumatic neurological disability. The identification of markers that differentiate disease progression is critical to effective therapy. A combination of NMR spectroscopic metabolic profiling of urine and statistical pattern recognition was used to detect focal inflammatory central nervous system (CNS) lesions induced by microinjection of a replication-deficient recombinant adenovirus expressing TNF-alpha or IL1-beta cDNA into the brains of Wistar rats. These animals were compared with a group of naïve rats and a group of animals injected with an equivalent null adenovirus. Urine samples were collected 7 days after adenovirus injection, when the inflammatory lesion is maximally active. Principal components analysis and Partial Least Squares-Discriminate analysis of the urine (1)H NMR spectra revealed significant differences between each of the cytokine adenovirus groups and the control groups; for the TNF-alpha group the main differences lay in citrate and succinate, while for the IL-1beta group the predominant changes occurred in leucine, isoleucine, valine and myo-inositol. Thus, we can identify urinary metabolic vectors that not only separate rats with inflammatory lesions in the brain from control animals, but also distinguish between different types of CNS inflammatory lesions.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Science
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Multiple Sclerosis
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Metabolomics
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Metabonomics
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Pattern Recognition
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Inmunología
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dc.subject.classification
Medicina Básica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Study of cytokine induced neuropathology by high resolution proton NMR spectroscopy of rat urine
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-04-10T13:39:15Z
dc.identifier.eissn
1873-3468
dc.journal.volume
568
dc.journal.number
1-3
dc.journal.pagination
49-54
dc.journal.pais
Países Bajos
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dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Griffin, Julian L.. University of Cambridge; Reino Unido
dc.description.fil
Fil: Anthony, Daniel C.. University of Southampton; Reino Unido
dc.description.fil
Fil: Campbell, Sandra J.. University of Southampton; Reino Unido
dc.description.fil
Fil: Gauldie, Jack. McMaster University; Canadá
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Fil: Pitossi, Fernando Juan. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
dc.description.fil
Fil: Styles, Peter. McMaster University; Canadá
dc.description.fil
Fil: Sibson, Nicola R.. University of Oxford; Reino Unido
dc.journal.title
FEBS Letters
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://febs.onlinelibrary.wiley.com/doi/abs/10.1016/j.febslet.2004.04.096
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.febslet.2004.04.096
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