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dc.contributor.author
Cabrera, Gabriel
dc.contributor.author
Fernández Brando, Romina Jimena
dc.contributor.author
Mejias, María Pilar
dc.contributor.author
Ramos, Maria Victoria
dc.contributor.author
Abrey Recalde, Maria Jimena
dc.contributor.author
Vanzulli, Silvia
dc.contributor.author
Vermeulen, Elba Monica
dc.contributor.author
Palermo, Marina Sandra
dc.date.available
2018-04-19T20:08:05Z
dc.date.issued
2015-09
dc.identifier.citation
Cabrera, Gabriel; Fernández Brando, Romina Jimena; Mejias, María Pilar; Ramos, Maria Victoria; Abrey Recalde, Maria Jimena; et al.; Leukotriene C4 increases the susceptibility of adult mice to Shigatoxin-producing Escherichia coli infection; Elsevier Gmbh; International Journal of Medical Microbiology (print); 305; 8; 9-2015; 910-917
dc.identifier.issn
1438-4221
dc.identifier.uri
http://hdl.handle.net/11336/42751
dc.description.abstract
tShiga toxin-producing Escherichia coli (STEC) is a food-borne pathogen that causes hemorrhagic colitis.Under some circumstances, Shiga toxin (Stx) produced within the intestinal tract enters the bloodstream,leading to systemic complications that may cause the potentially fatal hemolytic-uremic syndrome(HUS). Despite STEC human infection is characterized by acute inflammation of the colonic mucosa,little is known regarding the role of proinflammatory mediators like cysteine leukotrienes (cysLTs) inthis pathology. Thus, the aim of this work was to analyze whether leukotriene C4 (LTC4) influences STECpathogenesis in mice. We report that exogenous LTC4 pretreatment severely affected the outcome of STECgastrointestinal infection. LTC4-pretreated (LTC4+) and STEC-infected (STEC+) mice showed an increasedintestinal damage by histological studies, and a decreased survival compared to LTC4-non-pretreated(LTC4−) and STEC+ mice. LTC4+/STEC+ mice that died after the infection displayed neutrophilia andhigh urea levels, indicating that the cause of death was related to Stx2-toxicity. Despite the differencesobserved in the survival between LTC4+ and LTC4− mice after STEC infection, both groups showed thesame survival after Stx2-intravenous inoculation. In addition, LTC4 pretreatment increased the perme-ability of mucosal intestinal barrier, as assessed by FITC-dextran absorption experiments. Altogetherthese results suggest that LTC4 detrimental effect on STEC infection is related to the increased passageof pathogenic factors to the bloodstream.Finally, we showed that STEC infection per se increases the endogenous LTC4 levels in the gut, suggestingthat this inflammatory mediator plays a role in the pathogenicity of STEC infection in mice, mainly bydisrupting the mucosal epithelial barrier.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Gmbh
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
Leukotriene C4
dc.subject
Stec
dc.subject
Shiga Toxin
dc.subject
Hemolytic Uremic Syndrome
dc.subject.classification
Enfermedades Infecciosas
dc.subject.classification
Ciencias de la Salud
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Leukotriene C4 increases the susceptibility of adult mice to Shigatoxin-producing Escherichia coli infection
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-04-09T19:05:50Z
dc.identifier.eissn
1618-0607
dc.journal.volume
305
dc.journal.number
8
dc.journal.pagination
910-917
dc.journal.pais
Alemania
dc.journal.ciudad
Munich
dc.description.fil
Fil: Cabrera, Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
dc.description.fil
Fil: Fernández Brando, Romina Jimena. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
dc.description.fil
Fil: Mejias, María Pilar. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
dc.description.fil
Fil: Ramos, Maria Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
dc.description.fil
Fil: Abrey Recalde, Maria Jimena. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
dc.description.fil
Fil: Vanzulli, Silvia. Academia Nacional de Medicina de Buenos Aires; Argentina
dc.description.fil
Fil: Vermeulen, Elba Monica. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
dc.description.fil
Fil: Palermo, Marina Sandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
dc.journal.title
International Journal of Medical Microbiology (print)
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1438422115300102?via%3Dihub
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.ijmm.2015.09.006
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/pmid/26456732
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