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Artículo

Foot-and-mouth disease virus infection of dendritic cells triggersphosphorylation of ERK1/2 inducing class I presentation and apoptosis

Langellotti, Cecilia AnaIcon ; Cesar, Gonzalo; Soria, IvanaIcon ; Quattrocchi, ValeriaIcon ; Jancic, Carolina CristinaIcon ; Zamorano, Patricia InesIcon ; Vermeulen, Elba MonicaIcon
Fecha de publicación: 07/2015
Editorial: Elsevier
Revista: Vaccine
ISSN: 0264-410X
e-ISSN: 1873-2518
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Ciencias Veterinarias

Resumen

Foot-and-mouth disease (FMD) is a highly contagious viral disease of cloven-hoofed animals. This pathol-ogy is caused by foot-and-mouth disease virus (FMDV). Over time, the development of vaccines to preventthe spread of this illness became essential. Vaccines currently used contain the inactivated form of thevirus. However, vaccination generates an immune response different to that induced by the infection. Weinvestigated whether these differences are related to intracellular mechanisms on dendritic cells (DCs).As a result, we demonstrated that the internalization of infective virus triggered the phosphorylation ofERK1/2, which was involved in the activation of caspase-9, the intrinsic pathway of apoptosis and thedelivery of viral peptides on MHC class I molecules. While, inactivated virus (iFMDV) did not affect thispathway or any function mediated by its activation. As described, infectious virus in DCs was also asso-ciated to autophagy LC3 protein and was associated to lysosomal protein Lamp-2; contrary to observefor the iFMDV. Strikingly, the processing of viral antigens to accommodate in class I molecules doesnot appear to involve the proteasome. Finally, this increased presentation promotes a specific cytotoxicresponse against infectious virus.
Palabras clave: Foot-And-Mouth Disease Virus , Dendritic Cells , Mitogen-Activated Protein Kinase , Major Histocompatibility Calss I
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/42750
DOI: http://dx.doi.org/10.1016/j.vaccine.2015.07.038
URL: https://www.sciencedirect.com/science/article/pii/S0264410X15009858?via%3Dihub
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Articulos(IMEX)
Articulos de INST.DE MEDICINA EXPERIMENTAL
Citación
Langellotti, Cecilia Ana; Cesar, Gonzalo; Soria, Ivana; Quattrocchi, Valeria; Jancic, Carolina Cristina; et al.; Foot-and-mouth disease virus infection of dendritic cells triggersphosphorylation of ERK1/2 inducing class I presentation and apoptosis; Elsevier; Vaccine; 33; 38; 7-2015; 4945-4953
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