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dc.contributor.author
Trombetta, E. Sergio  
dc.contributor.author
Parodi, Armando José A.  
dc.date.available
2018-04-19T17:47:23Z  
dc.date.issued
2005-04  
dc.identifier.citation
Trombetta, E. Sergio; Parodi, Armando José A.; Glycoprotein reglucosylation; Academic Press Inc Elsevier Science; Methods; 35; 4; 4-2005; 328-337  
dc.identifier.issn
1046-2023  
dc.identifier.uri
http://hdl.handle.net/11336/42692  
dc.description.abstract
Proteins following the secretory pathway acquire their proper tertiary and in certain cases also quaternary structures in the endoplasmic reticulum (ER). Incompletely folded species are retained in the ER and eventually degraded. One of the molecular mechanisms by which cells achieve this conformational sorting is based on monoglucosylated N-glycans (Glc1Man5-9GlcNAc2) present on nascent glycoproteins in the ER. This chapter discusses two of the steps that regulate the abundance of such N-glycan structures, including glycoprotein deglucosylation (by glucosidase II) and reglucosylation (by the UDP-Glc:glycoprotein glucosyltransferase), as well as an overview of methods to evaluate the N-glycans prevalent during glycoprotein biogenesis in the ER.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Academic Press Inc Elsevier Science  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Glycoproteins  
dc.subject.classification
Otras Ciencias Biológicas  
dc.subject.classification
Ciencias Biológicas  
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS  
dc.title
Glycoprotein reglucosylation  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2018-04-05T19:23:06Z  
dc.identifier.eissn
1095-9130  
dc.journal.volume
35  
dc.journal.number
4  
dc.journal.pagination
328-337  
dc.journal.pais
Estados Unidos  
dc.journal.ciudad
San Diego  
dc.description.fil
Fil: Trombetta, E. Sergio. University of Yale; Estados Unidos  
dc.description.fil
Fil: Parodi, Armando José A.. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina  
dc.journal.title
Methods  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1046202304002300  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.ymeth.2004.10.004  

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