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dc.contributor.author Ávila Maniero, Mariángeles
dc.contributor.author Guerrero Gimenez, Martin Eduardo
dc.contributor.author Fanelli, Mariel Andrea
dc.contributor.author Wuilloud, Rodolfo German
dc.date.available 2018-04-18T18:45:42Z
dc.date.issued 2017-11
dc.identifier.citation Ávila Maniero, Mariángeles; Guerrero Gimenez, Martin Eduardo; Fanelli, Mariel Andrea; Wuilloud, Rodolfo German; Inorganic mercury in mammary cells: viability, metal uptake but efflux?; Springer; Biometals; 31; 1; 11-2017; 69-80
dc.identifier.issn 0966-0844
dc.identifier.uri http://hdl.handle.net/11336/42522
dc.description.abstract The viability, cellular uptake and subcellular distribution of heavy metal Hg, were determined in human mammary cell lines (MCF-7, MDA-MB-231 and MCF-10A). It was observed that Hg had the capacity of being excluded from the cells with a different type of possible transporters. MCF-7 cells showed the lowest viability, while the other two cell lines were much more resistant to Hg treatments. The intracellular concentration of Hg was higher at lower exposure times in MCF-10A cells and MCF-7 cells; but as the time was increased only MDA-MB-231 showed the capacity to continue introducing the metal. In MCF-7 and MCF-10A cells the subcellular distribution of Hg was higher in cytosolic fraction than nucleus and membrane, but MDA-MB-231 showed membrane and nucleus fraction as the enriched one. The analysis of RNA-seq about the genes or family of genes that encode proteins which are related to cytotoxicity of Hg evidenced that MCF-10A cells and MCF-7 cells could have an active transport to efflux the metal. On the contrary, in MDA-MB-231 no genes that could encode active transporters have been found.
dc.format application/pdf
dc.language.iso eng
dc.publisher Springer
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject Human mammary cell lines
dc.subject Mercury
dc.subject Transporters
dc.subject.classification Otras Ciencias Biológicas
dc.subject.classification Ciencias Biológicas
dc.subject.classification CIENCIAS NATURALES Y EXACTAS
dc.title Inorganic mercury in mammary cells: viability, metal uptake but efflux?
dc.type info:eu-repo/semantics/article
dc.type info:ar-repo/semantics/artículo
dc.type info:eu-repo/semantics/publishedVersion
dc.date.updated 2018-04-16T13:47:11Z
dc.journal.volume 31
dc.journal.number 1
dc.journal.pagination 69-80
dc.journal.pais Alemania
dc.journal.ciudad Berlin
dc.description.fil Fil: Ávila Maniero, Mariángeles. Universidad "Juan Agustín Maza"; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Exactas y Naturales. Laboratorio de Química Analítica para Investigación y Desarrollo; Argentina
dc.description.fil Fil: Guerrero Gimenez, Martin Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
dc.description.fil Fil: Fanelli, Mariel Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
dc.description.fil Fil: Wuilloud, Rodolfo German. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Exactas y Naturales. Laboratorio de Química Analítica para Investigación y Desarrollo; Argentina
dc.journal.title Biometals
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs10534-017-0068-0
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1007/s10534-017-0068-0
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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)