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dc.contributor.author
Santpere, Gabriel
dc.contributor.author
Carnero Montoro, Elena
dc.contributor.author
Petit, Natalia
dc.contributor.author
Serra, François
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Heredia Genestar, José, María
dc.contributor.author
Halligan, Daniel
dc.contributor.author
Dopazo, Hernán Javier
dc.contributor.author
Navarro, Arcadi
dc.contributor.author
Bosch, Elena
dc.date.available
2018-04-16T15:16:18Z
dc.date.issued
2015-06-24
dc.identifier.citation
Santpere, Gabriel; Carnero Montoro, Elena; Petit, Natalia; Serra, François; Heredia Genestar, José, María; et al.; Analysis of Five Gene Sets in Chimpanzees Suggests Decoupling between the Action of Selection on Protein-Coding and on Noncoding Elements; Oxford Academics; Genome Biology and Evolution; 7; 6; 24-6-2015; 1490-1505
dc.identifier.issn
1759-6653
dc.identifier.uri
http://hdl.handle.net/11336/42119
dc.description.abstract
We set out to investigate potential differences and similitudes between the selective forces acting upon the coding and non-coding regions of five different sets of genes defined according to functional and evolutionary criteria: i) two reference gene sets presenting accelerated and slow rates of protein evolution (the Complement and Actin pathways), ii) a set of genes with evidence of accelerated evolution in at least one of their introns; and iii) two gene sets related to neurological function (Parkinson´s and Alzheimer´s diseases). To that effect, we combine human-chimpanzee divergence patterns with polymorphism data obtained from target resequencing 20 central chimpanzees, our closest relatives with largest long-term effective population size. By using the DFE-alpha extension of the McDonald-Kreitman test, we reproduce inferences of rates of evolution previously based only on divergence data on both coding and intronic sequences and also obtain inferences for other classes of genomics elements (UTRs, promoters and conserved non-coding sequences (CNS)). Our results suggest that (i) DFE-alpha method successfully helps distinguishing different scenarios of accelerated divergence (adaptation or relaxed selective constraints); and (ii) the adaptive history of coding and non-coding sequences within the gene sets analyzed may transcur independently.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Oxford Academics
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Genomica
dc.subject
Seleccion Positiva
dc.title
Analysis of Five Gene Sets in Chimpanzees Suggests Decoupling between the Action of Selection on Protein-Coding and on Noncoding Elements
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-04-10T20:09:10Z
dc.journal.volume
7
dc.journal.number
6
dc.journal.pagination
1490-1505
dc.journal.pais
Reino Unido
dc.journal.ciudad
Oxford
dc.description.fil
Fil: Santpere, Gabriel. Universitat Pompeu Fabra; España
dc.description.fil
Fil: Carnero Montoro, Elena. Universitat Pompeu Fabra; España
dc.description.fil
Fil: Petit, Natalia. Universitat Pompeu Fabra; España
dc.description.fil
Fil: Serra, François. Centre Nacional d’Analisi Genómica; España
dc.description.fil
Fil: Heredia Genestar, José, María. Universitat Pompeu Fabra; España
dc.description.fil
Fil: Halligan, Daniel. University of Edinburgh; Reino Unido
dc.description.fil
Fil: Dopazo, Hernán Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Ecología, Genética y Evolución de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Ecología, Genética y Evolución de Buenos Aires; Argentina
dc.description.fil
Fil: Navarro, Arcadi. Universitat Pompeu Fabra; España
dc.description.fil
Fil: Bosch, Elena. Universitat Pompeu Fabra; España
dc.journal.title
Genome Biology and Evolution
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/gbe/article/7/6/1490/2465671
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1093/gbe/evv082
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