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Artículo

Lipid second messengers and related enzymes in vertebrate rod outer segments

Giusto, Norma MariaIcon ; Pasquaré, Susana Juana; Salvador, Gabriela AlejandraIcon ; Ilincheta, Monica GracielaIcon
Fecha de publicación: 04/2010
Editorial: American Society for Biochemistry and Molecular Biology
Revista: Jlr Papers In Press
ISSN: 0022-2275
e-ISSN: 1539-7262
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Otras Ciencias de la Salud

Resumen

Rod outer segments (ROSs) are specialized light-sensitive organelles in vertebrate photoreceptor cells. Lipids in ROS are of considerable importance, not only in providing an adequate environment for efficient phototransduction, but also in originating the second messengers involved in signal transduction. ROSs have the ability to adapt the sensitivity and speed of their responses to ever-changing conditions of ambient illumination. A major contributor to this adaptation is the light-driven translocation of key signaling proteins into and out of ROS. The present review shows how generation of the second lipid messengers from phosphatidylcholine, phosphatidic acid, and diacylglycerol is modulated by the different illumination states in the vertebrate retina. Findings suggest that the light-induced translocation of phototransduction proteins influences the enzymatic activities of phospholipase D, lipid phosphate phosphatase, diacylglyceride lipase, and diacylglyceride kinase, all of which are responsible for the generation of the second messenger molecules.
Palabras clave: Diacylglycerol , Diacylglycerol Kinase , Diacylglycerol Lipase , Lipid Phosphate Phosphatase , Monoacylglycerol , Phosphatidic Acid , Phospholipase D
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/42087
DOI: http://dx.doi.org/10.1194/jlr.R001891
URL: http://www.jlr.org/content/51/4/685
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Articulos(INIBIBB)
Articulos de INST.DE INVEST.BIOQUIMICAS BAHIA BLANCA (I)
Citación
Giusto, Norma Maria; Pasquaré, Susana Juana; Salvador, Gabriela Alejandra; Ilincheta, Monica Graciela; Lipid second messengers and related enzymes in vertebrate rod outer segments; American Society for Biochemistry and Molecular Biology; Jlr Papers In Press; 51; 4; 4-2010; 685-700
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