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Artículo

Immunohistochemical expression of intrarenal renin angiotensin system components in response to tempol in rats fed a high salt diet

Cao, Gabriel FernandoIcon ; Della Penna, Silvana Lorena; Kouyoumdzian, Nicolás MartínIcon ; Choi, Marcelo RobertoIcon ; Gorzalczany, Susana Beatriz; Fernandez, Belisario EnriqueIcon ; Toblli, Jorge EduardoIcon ; Roson, Maria InesIcon
Fecha de publicación: 01/2017
Editorial: Baishideng Publishing Group
Revista: World Journal of Nephrology
ISSN: 2220-6124
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Patología

Resumen

AIM:To determine the effect of tempol in normal rats fed high salt on arterial pressure and the balance between antagonist components of the renal renin-angiotensin system.METHODS:Sprague-Dawley rats were fed with 8% NaCl high-salt (HS) or 0.4% NaCl (normal-salt, NS) diet for 3 wk, with or without tempol (T) (1 mmol/L, administered in drinking water). Mean arterial pressure (MAP), glomerular filtration rate (GFR), and urinary sodium excretion (UVNa) were measured. We evaluated angiotensin II (Ang II), angiotensin 1-7 (Ang 1-7), angiotensin converting enzyme 2 (ACE2), mas receptor (MasR), angiotensin type 1 receptor (AT1R) and angiotensin type 2 receptor (AT2R) in renal tissues by immunohistochemistry.RESULTS:The intake of high sodium produced a slight but significant increase in MAP and differentially regulated components of the renal renin-angiotensin system (RAS). This included an increase in Ang II and AT1R, and decrease in ACE-2 staining intensity using immunohistochemistry. Antioxidant supplementation with tempol increased natriuresis and GFR, prevented changes in blood pressure and reversed the imbalance of renal RAS components. This includes a decrease in Ang II and AT1R, as increase in AT2, ACE2, Ang (1-7) and MasR staining intensity using immunohistochemistry. In addition, the natriuretic effects of tempol were observed in NS-T group, which showed an increased staining intensity of AT2, ACE2, Ang (1-7) and MasR.CONCLUSION:These findings suggest that a high salt diet leads to changes in the homeostasis and balance between opposing components of the renal RAS in hypertension to favour an increase in Ang II. Chronic antioxidant supplementation can modulate the balance between the natriuretic and antinatriuretic components of the renal RAS.
Palabras clave: Angiotensin 1-7 , Angiotensin Ii , High Sodium Diet , Kidney , Tempol
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/41997
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5215206/
DOI: https://dx.doi.org/10.5527%2Fwjn.v6.i1.29
URL: https://www.wjgnet.com/2220-6124/full/v6/i1/29.htm
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Articulos(ININCA)
Articulos de INST.DE INVEST.CARDIOLOGICAS (I)
Citación
Cao, Gabriel Fernando; Della Penna, Silvana Lorena; Kouyoumdzian, Nicolás Martín; Choi, Marcelo Roberto; Gorzalczany, Susana Beatriz; et al.; Immunohistochemical expression of intrarenal renin angiotensin system components in response to tempol in rats fed a high salt diet; Baishideng Publishing Group; World Journal of Nephrology; 6; 1; 1-2017; 29-40
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