Mostrar el registro sencillo del ítem
dc.contributor.author
José, Carla
dc.contributor.author
Toledo, Victoria
dc.contributor.author
Briand, Laura Estefania
dc.date.available
2018-04-11T21:20:19Z
dc.date.issued
2015-06-30
dc.identifier.citation
José, Carla; Toledo, Victoria; Briand, Laura Estefania; Enzymatic kinetic resolution of racemic ibuprofen: past, present and future; Taylor & Francis; Critical Reviews In Biotechnology; 36; 5; 30-6-2015; 891-903
dc.identifier.issn
0738-8551
dc.identifier.uri
http://hdl.handle.net/11336/41825
dc.description.abstract
This review is a journey concerning the investigations of the kinetic resolution of racemic ibuprofen for the last 20 years. The relevancy of the pharmacological uses of the S( + ) enantiomer along with its higher cost compared with racemic profen are the driving forces of a variety of scientific research studies addressing the enzymatic resolution of ibuprofen through enantiomeric esterification using lipases as biocatalysts. Lipases of fungal sources such as Candida rugosa, Rhizomucor miehei and the lipase B of Candida antarctica have been extensively studied both in homogeneous and heterogeneous (immobilized on solid supports) processes. In this context, the various alcohols and organic co-solvents frequently used in the esterification of racemic ibuprofen are summarized and discussed in this review. Moreover, recent investigations using membranes as reactors coupled with the separation of the desired product and microfluidic devices are presented. Finally, some guidelines about future perspectives regarding the technology of the kinetic resolution of profens and research niches are given.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Taylor & Francis
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Enantiomeric Esterification
dc.subject
Ibuprofen
dc.subject
Kinetic Resolution
dc.subject
Lipases
dc.subject.classification
Biotecnología Industrial
dc.subject.classification
Biotecnología Industrial
dc.subject.classification
INGENIERÍAS Y TECNOLOGÍAS
dc.title
Enzymatic kinetic resolution of racemic ibuprofen: past, present and future
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-04-05T18:37:36Z
dc.identifier.eissn
1549-7801
dc.journal.volume
36
dc.journal.number
5
dc.journal.pagination
891-903
dc.journal.pais
Reino Unido
dc.journal.ciudad
Londres
dc.description.fil
Fil: José, Carla. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigación y Desarrollo en Ciencias Aplicadas ; Argentina
dc.description.fil
Fil: Toledo, Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigación y Desarrollo en Ciencias Aplicadas ; Argentina
dc.description.fil
Fil: Briand, Laura Estefania. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigación y Desarrollo en Ciencias Aplicadas ; Argentina
dc.journal.title
Critical Reviews In Biotechnology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3109/07388551.2015.1057551
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/full/10.3109/07388551.2015.1057551
Archivos asociados