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dc.contributor.author
Rodriguez Granillo, Gaston Alfredo  
dc.contributor.author
Carrascosa, Patricia  
dc.contributor.author
Bruining, Nico  
dc.date.available
2018-04-11T21:11:17Z  
dc.date.issued
2016-06  
dc.identifier.citation
Rodriguez Granillo, Gaston Alfredo; Carrascosa, Patricia; Bruining, Nico; Progression of coronary artery calcification at the crossroads: sign of progression or stabilization of coronary atherosclerosis?; AME Publishing Company; Cardiovascular Diagnosis and Therapy; 6; 3; 6-2016; 250-258  
dc.identifier.issn
2223-3660  
dc.identifier.uri
http://hdl.handle.net/11336/41811  
dc.description.abstract
Coronary artery calcification (CAC) has been strongly established as an independent predictor of adverse events, with a significant incremental prognostic value over traditional risk stratification algorithms. CAC progression has been associated with a higher rate of events. In parallel, several randomized studies and meta-analysis have shown the effectiveness of statins to slow progression and even promote plaque regression. However, evidence regarding the effect of routine medical therapy on CAC has yielded conflicting results, with initial studies showing significant CAC regression, and contemporaneous data showing rather the opposite. Accordingly, there is currently a great controversy on whether progression of CAC is a sign of progression or stabilization of coronary artery disease (CAD). The finding of inexorable CAC progression despite the implementation of intensive contemporaneous medical therapy suggests that further understanding of this phenomenon should be undertaken before the implementation of CAC as a surrogate endpoint for longitudinal studies, or for prospective follow-up of patients under routine medical treatment.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
AME Publishing Company  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Prognostic Value  
dc.subject
Longitudinal Studies  
dc.subject
Atherothrombosis  
dc.subject
Imaging  
dc.subject
Statin  
dc.subject.classification
Medicina Critica y de Emergencia  
dc.subject.classification
Medicina Clínica  
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CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
Progression of coronary artery calcification at the crossroads: sign of progression or stabilization of coronary atherosclerosis?  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2018-04-10T20:29:13Z  
dc.journal.volume
6  
dc.journal.number
3  
dc.journal.pagination
250-258  
dc.journal.pais
China  
dc.journal.ciudad
Hong Kong  
dc.description.fil
Fil: Rodriguez Granillo, Gaston Alfredo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina. Diagnóstico Maipú; Argentina  
dc.description.fil
Fil: Carrascosa, Patricia. Diagnóstico Maipú; Argentina  
dc.description.fil
Fil: Bruining, Nico. Erasmus MC; Países Bajos  
dc.journal.title
Cardiovascular Diagnosis and Therapy  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://cdt.amegroups.com/article/view/9556/10965  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.21037/cdt.2016.03.03