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dc.contributor.author
Santos, Gesivaldo
dc.contributor.author
Giraldez Alvarez, Lisandro Diego
dc.contributor.author
Ávila Rodriguez, Marco
dc.contributor.author
Capani, Francisco
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dc.contributor.author
Galembeck, Eduardo
dc.contributor.author
Gôes Neto, Aristóteles
dc.contributor.author
Barreto, George E.
dc.contributor.author
Andrade, Bruno
dc.date.available
2018-04-11T21:10:24Z
dc.date.issued
2016-08
dc.identifier.citation
Santos, Gesivaldo; Giraldez Alvarez, Lisandro Diego; Ávila Rodriguez, Marco; Capani, Francisco; Galembeck, Eduardo; et al.; SUR1 Receptor Interaction with Hesperidin and Linarin Predicts Possible Mechanisms of Action of Valeriana officinalis in Parkinson.; Frontiers; Frontier in aging neurosci; 8; 97; 8-2016; 1-12
dc.identifier.issn
1663-4365
dc.identifier.uri
http://hdl.handle.net/11336/41805
dc.description.abstract
Parkinson's disease (PD) is one of the most common neurodegenerative disorders. A theoretical approach of our previous experiments reporting the cytoprotective effects of the Valeriana officinalis compounds extract for PD is suggested. In addiction to considering the PD as a result of mitochondrial metabolic imbalance and oxidative stress, such as in our previous in vitro model of rotenone, in the present manuscript we added a genomic approach to evaluate the possible underlying mechanisms of the effect of the plant extract. Microarray of substantia nigra (SN) genome obtained from Allen Brain Institute was analyzed using gene set enrichment analysis to build a network of hub genes implicated in PD. Proteins transcribed from hub genes and their ligands selected by search ensemble approach algorithm were subjected to molecular docking studies, as well as 20 ns Molecular Dynamics (MD) using a Molecular Mechanic Poison/Boltzman Surface Area (MMPBSA) protocol. Our results bring a new approach to Valeriana officinalis extract, and suggest that hesperidin, and probably linarin are able to relieve effects of oxidative stress during ATP depletion due to its ability to binding SUR1. In addition, the key role of valerenic acid and apigenin is possibly related to prevent cortical hyperexcitation by inducing neuronal cells from SN to release GABA on brain stem. Thus, under hyperexcitability, oxidative stress, asphyxia and/or ATP depletion, Valeriana officinalis may trigger different mechanisms to provide neuronal cell protection.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Frontiers
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Parkinson
dc.subject
In Silico
dc.subject
Valerina
dc.subject
Linarin
dc.subject.classification
Inmunología
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dc.subject.classification
Medicina Básica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
SUR1 Receptor Interaction with Hesperidin and Linarin Predicts Possible Mechanisms of Action of Valeriana officinalis in Parkinson.
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-04-10T20:29:02Z
dc.journal.volume
8
dc.journal.number
97
dc.journal.pagination
1-12
dc.journal.pais
Suiza
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dc.description.fil
Fil: Santos, Gesivaldo. Universidade Estadual do Sudoeste da Bahia; Brasil
dc.description.fil
Fil: Giraldez Alvarez, Lisandro Diego. Universidade Estadual do Sudoeste da Bahia; Brasil
dc.description.fil
Fil: Ávila Rodriguez, Marco. Pontificia Universidad Javeriana; Colombia
dc.description.fil
Fil: Capani, Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina
dc.description.fil
Fil: Galembeck, Eduardo. Universidade Estadual de Campinas; Brasil
dc.description.fil
Fil: Gôes Neto, Aristóteles. Universidade Estadual de Feira de Santana; Brasil
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Fil: Barreto, George E.. Pontificia Universidad Javeriana; Colombia
dc.description.fil
Fil: Andrade, Bruno. Universidade Estadual do Sudoeste da Bahia; Brasil
dc.journal.title
Frontier in aging neurosci
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3389/fnagi.2016.00097
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fnagi.2016.00097/full
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