The Thioredoxins Protein System: a Key Target in Perinatal Asphyxia

Abstract

Hypoxia during birth is one of the leading childhood mortality worldwide and results in many neurodisabled survivors. Several lines of evidence demonstrated that reactive oxygen species are the final step in the metabolicdisorders produced by a deficit of oxygen. However, any specific therapy has been effective to ameliorate the devastating consequences of perinatal asphyxia. In the last few years, the Thioredoxin Family Protein has emerged as akey player in the regulation of the redox state of the cells in normal and pathological conditions. This review summarizes new insight of the role of Trxs, Prxs and Grxs in physiopathology of perinatal asphyxia.