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dc.contributor.author
Fiore, Esteban Juan
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dc.contributor.author
Mazzolini Rizzo, Guillermo Daniel
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dc.contributor.author
Aquino, Jorge Benjamin
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dc.date.available
2018-04-11T19:11:15Z
dc.date.issued
2015-08
dc.identifier.citation
Fiore, Esteban Juan; Mazzolini Rizzo, Guillermo Daniel; Aquino, Jorge Benjamin; Mesenchymal Stem/Stromal Cells in Liver Fibrosis: Recent Findings, Old/New Caveats and Future Perspectives; Springer Heidelberg; Stem Cell Reviews And Reports; 11; 4; 8-2015; 586-597
dc.identifier.issn
1550-8943
dc.identifier.uri
http://hdl.handle.net/11336/41768
dc.description.abstract
Mesenchymal stem/stromal cells (MSCs) are progenitors which share plastic-adherence capacity and cell surface markers but have different properties according to their cell and tissue sources and to culture conditions applied. Many recent publications suggest that MSCs can differentiate into hepatic-like cells, which can be a consequence of either a positive selection of rare in vivo pluripotent cells or of the original plasticity of some cells contributing toMSC cultures. Apossible role of MSCs in hereditary transmission of obesity and/or diabetes as well as properties of MSCs regarding immunomodulation, cell fusion and exosome release capacities are discussed according to recent literature. Limitations in methods used to track MSCs in vivo especially in the context of liver cirrhosis are addressed as well as strategies explored to enhance their migratory, survival and proliferation properties, which are known to be relevant for their future clinical use. Current knowledge regarding mechanisms involved in liver cirrhosis ameliorationmediated by naïve and genetically modified MSCs as well as the effects of applying preconditioning and combined strategies to improve their therapeutic effects are evaluated. Finally, first reports of GMP guidelines and biosafety issues in MSCs applications are discussed.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Springer Heidelberg
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
BIODISTRIBUTION
dc.subject
BIOSAFETY
dc.subject
CELL SOURCE
dc.subject
CIRRHOSIS
dc.subject
HEPATOCYTE-LIKE CELLS
dc.subject
IGF-I
dc.subject
MECHANISMS
dc.subject
MESENCHYMAL STEMCELLS
dc.subject
NEURAL CREST
dc.subject.classification
Otras Medicina Básica
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dc.subject.classification
Medicina Básica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Mesenchymal Stem/Stromal Cells in Liver Fibrosis: Recent Findings, Old/New Caveats and Future Perspectives
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-04-11T15:15:33Z
dc.journal.volume
11
dc.journal.number
4
dc.journal.pagination
586-597
dc.journal.pais
Alemania
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dc.journal.ciudad
Heidelberg
dc.description.fil
Fil: Fiore, Esteban Juan. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Austral. Facultad de Ciencias Biomédicas. Laboratorio de Terapia Genética; Argentina
dc.description.fil
Fil: Mazzolini Rizzo, Guillermo Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Austral. Facultad de Ciencias Biomédicas. Laboratorio de Terapia Genética; Argentina
dc.description.fil
Fil: Aquino, Jorge Benjamin. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Austral. Facultad de Ciencias Biomédicas. Laboratorio de Terapia Genética; Argentina
dc.journal.title
Stem Cell Reviews And Reports
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs12015-015-9585-9
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/s12015-015-9585-9
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