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dc.contributor.author
Queiroz, Alvaro Antonio Alencar de
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Abraham, Gustavo Abel
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Camilo, María Aparecida Pires
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Higa, Olga Zazuco
dc.contributor.author
Silva, Gerald Saraiva
dc.contributor.author
Fernández, María del Mar
dc.contributor.author
San Roman, Julio
dc.date.available
2018-04-11T15:09:11Z
dc.date.issued
2006-01-03
dc.identifier.citation
Queiroz, Alvaro Antonio Alencar de; Abraham, Gustavo Abel; Camilo, María Aparecida Pires; Higa, Olga Zazuco; Silva, Gerald Saraiva; et al.; Physicochemical and antimicrobial properties of boron-complexed polyglycerol–chitosan dendrimers; Vsp Bv; Journal of Biomaterials Science - Polymer Edition; 17; 6; 3-1-2006; 689-707
dc.identifier.issn
0920-5063
dc.identifier.uri
http://hdl.handle.net/11336/41701
dc.description.abstract
A polyglycerol with dendritic structure (PGLD) was synthesized by ring-opening polymerization of deprotonated glycidol using a polyglycerol as core functionality in a step-growth process. Then, PGLD reacted with O-carboxymethylated chitosan to obtain PGLD-chitosan dendrimer (PGLD-Ch). After the reaction of PGLD-Ch with boric acid, there was a marked increase in the bulk viscosity evidencing physically that boron can initiate a charge transfer complex formation, (PGLD-Ch)B. Gel permeation chromatography analysis was used to characterize the molecular weight and the polydispersivity of the synthesized PGLD-Ch. A dendritic structure with a molecular mass of 16.7 kDa and a narrow polydispersity (M w/M n = 1.05) was obtained. 1H-NMR and 13C-NMR measurements were employed to assess the degree of branching in PGLD. The obtained value of 0.85 indicates the tendency toward a dentritic structure for PGLD. The glass transition temperature values of (PGLD-Ch)B membranes containing 10% and 30% PGLD were −19°C and −26°C, respectively, which favor its potential use as surface coating of several polymers. The in vitro cytotoxicity was evaluated using the minimum essential medium elution test assay. Extracts of boroncomplexed PGLD exhibited lower cytotoxicity than the controls, suggesting that the material has an improved biocompatibility. Antibacterial studies of (PGLD-Ch)B against Staphylococcus aureus and Pseudomonas aeruginosa showed a significant activity. Our study confirms and supports the effectiveness of (PGLD-Ch)B as an antimicrobial coating due to its capacity in suppressing the bacterial proliferation. The best in vivo response was found for (PGLD-Ch)B-30 membranes, which exhibited higher synthesis of collagen fibers than PGLD-ChB-10.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Vsp Bv
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Polyglycerol
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Chitosan
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Dendrimers
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Antimicrobial Properties
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Wound Healing
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Otras Biotecnologías de la Salud
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Biotecnología de la Salud
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CIENCIAS MÉDICAS Y DE LA SALUD
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Nano-materiales
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Nanotecnología
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INGENIERÍAS Y TECNOLOGÍAS
dc.title
Physicochemical and antimicrobial properties of boron-complexed polyglycerol–chitosan dendrimers
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-04-05T18:35:46Z
dc.journal.volume
17
dc.journal.number
6
dc.journal.pagination
689-707
dc.journal.pais
Países Bajos
dc.journal.ciudad
Leiden
dc.description.fil
Fil: Queiroz, Alvaro Antonio Alencar de. Universidade Federal de Itajubá; Brasil
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Fil: Abraham, Gustavo Abel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
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Fil: Camilo, María Aparecida Pires. Comissao Nacional de Energia Nuclear. Centro de Lasers e Aplicacoes. Instituto de Pesquisas Energeticas e Nucleares.; Brasil
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Fil: Higa, Olga Zazuco. Comissao Nacional de Energia Nuclear. Centro de Lasers e Aplicacoes. Instituto de Pesquisas Energeticas e Nucleares.; Brasil
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Fil: Silva, Gerald Saraiva. Comissao Nacional de Energia Nuclear. Centro de Lasers e Aplicacoes. Instituto de Pesquisas Energeticas e Nucleares.; Brasil
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Fil: Fernández, María del Mar. Instituto en Ciencia y Tecnología de Polímeros; España
dc.description.fil
Fil: San Roman, Julio. Instituto en Ciencia y Tecnología de Polímeros; España
dc.journal.title
Journal of Biomaterials Science - Polymer Edition
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1163/156856206777346313
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/abs/10.1163/156856206777346313
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