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dc.contributor.author
Torralva, Teresa
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dc.contributor.author
Sposato, Luciano A.
dc.contributor.author
Riccio, Patricia M.
dc.contributor.author
Gleichgerrcht, Ezequiel
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dc.contributor.author
Roca, María
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dc.contributor.author
Toledo, John B.
dc.contributor.author
Trojanowski, John Q.
dc.contributor.author
Kukull, Walter A.
dc.contributor.author
Manes, Facundo Francisco
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dc.contributor.author
Hachinski, Vladimir
dc.date.available
2018-04-10T18:08:18Z
dc.date.issued
2015-06
dc.identifier.citation
Torralva, Teresa; Sposato, Luciano A.; Riccio, Patricia M.; Gleichgerrcht, Ezequiel; Roca, María; et al.; Role of brain infarcts in behavioral variant frontotemporal dementia: Clinicopathological characterization in the National Alzheimer's Coordinating Center database; Elsevier Science Inc; Neurobiology of Aging; 36; 10; 6-2015; 2861-2868
dc.identifier.issn
0197-4580
dc.identifier.uri
http://hdl.handle.net/11336/41555
dc.description.abstract
Diagnosing behavioral variant frontotemporal dementia (bvFTD) in patients with prior history of stroke or with silent brain infarcts on neuroimaging studies can be challenging. Vascular changes in patients with bvFTD are not unusual, but bvFTD tends to be ruled out in the presence of cerebrovascular disease. We aimed to identify the clinical, cognitive, and risk factor profile of bvFTD with coexistent cerebrovascular disease (V-bvFTD). We compared demographic data, clinical diagnoses, vascular risk factors, functional status, and normalized neuropsychological z-scores between patients with V-bvFTD versus bvFTD without concomitant cerebrovascular disease (NV-bvFTD) from the National Alzheimer's Coordinating Centre database. We included 391 neuropathologically-diagnosed cases of frontotemporal lobe degeneration. We excluded patients that were diagnosed with aphasic variants of frontotemporal dementia before death. Patients with V-bvFTD (n = 62) were older at the time of onset of cognitive decline (71.6 vs. 62.5 years, p < 0.001) and death (78.7 vs. 69.6, p < 0.001), more likely to be hypertensive (75.8% vs. 45.7%, p = 0.002) and to have a history of stroke (21.2% vs. 6.1%, p = 0.007) than those with NV-bvFTD (n = 329). V-bvFTD was often underdiagnosed, affected elderly patients, and had a similar cognitive profile as NV-bvFTD despite the presence of brain infarcts. In the whole cohort, we observed enhanced cognitive performance with increasing age quintiles despite larger proportions of cerebrovascular disease pathology, likely meaning that frontotemporal lobe degeneration–related primary neurodegeneration exerts a stronger impact on cognition than cerebrovascular disease. Coexisting cerebrovascular disease should not preclude the diagnosis of bvFTD.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Science Inc
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
Frontotemporal
dc.subject
Dementia
dc.subject
Vascular
dc.subject
Stroke
dc.subject
Risk
dc.subject
Infarct
dc.subject.classification
Inmunología
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dc.subject.classification
Medicina Básica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Role of brain infarcts in behavioral variant frontotemporal dementia: Clinicopathological characterization in the National Alzheimer's Coordinating Center database
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-04-10T14:20:14Z
dc.journal.volume
36
dc.journal.number
10
dc.journal.pagination
2861-2868
dc.journal.pais
Estados Unidos
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dc.description.fil
Fil: Torralva, Teresa. Instituto de Neurología Cognitiva; Argentina. Universidad Diego Portales; Chile. Universidad Favaloro; Argentina. Australian Research Council; Australia
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Fil: Sposato, Luciano A.. Western Ontario University; Canadá
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Fil: Riccio, Patricia M.. Western Ontario University; Canadá
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Fil: Gleichgerrcht, Ezequiel. Medical University of South Carolina,; Estados Unidos
dc.description.fil
Fil: Roca, María. Instituto de Neurología Cognitiva; Argentina. Universidad Diego Portales; Chile. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Toledo, John B.. University of Pennsylvania; Estados Unidos
dc.description.fil
Fil: Trojanowski, John Q.. University of Pennsylvania; Estados Unidos
dc.description.fil
Fil: Kukull, Walter A.. University of Washington; Estados Unidos
dc.description.fil
Fil: Manes, Facundo Francisco. Instituto de Neurología Cognitiva; Argentina. Universidad Diego Portales; Chile. Universidad Favaloro; Argentina. Australian Research Council; Australia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Hachinski, Vladimir. Western Ontario University; Canadá
dc.journal.title
Neurobiology of Aging
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.neurobiolaging.2015.06.026
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.neurobiologyofaging.org/article/S0197-4580(15)00338-3/fulltext
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