Artículo
High-throughput Drug Repositioning for the Discovery of New Treatments for Chagas Disease
Bellera, Carolina Leticia
; Sbaraglini, Maria Laura
; Balcazar, Dario Emmanuel
; Fraccaroli, Laura Virginia
; Vanrell, Maria Cristina
; Casassa, Ana Florencia
; Labriola, Carlos Alberto
; Romano, Patricia Silvia
; Carrillo, Carolina
; Talevi, Alan
Fecha de publicación:
03/2015
Editorial:
Bentham Science Publishers
Revista:
Mini-reviews In Medicinal Chemistry
ISSN:
1389-5575
e-ISSN:
1875-5607
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Despite affecting around 8 million people worldwide and representing an economic burden above $7 billion/ year, currently approved medications to treat Chagas disease are still limited to two drugs, nifurtimox and benznidazole, which were developed more than 40 years ago and present important efficacy and safety limitations. Drug repositioning (i.e. finding second or further therapeutic indications for known drugs) has raised considerable interest within the international drug development community. There are many explanations to the current interest on drug repositioning including the possibility to partially circumvent clinical trials and the consequent saving in time and resources. It has been suggested as a particular attractive approach for the development of novel therapeutics for neglected diseases, which are usually driven by public or non-profit organizations. Here we review current computer-guided approaches to drug repositioning and reports on drug repositioning stories oriented to Chagas disease, with a focus on computer-guided drug repositioning campaigns.
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Articulos(CCT - LA PLATA)
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - LA PLATA
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - LA PLATA
Articulos(ICT - MILSTEIN)
Articulos de INST.DE CS. Y TECNOLOGIA "DR. CESAR MILSTEIN"
Articulos de INST.DE CS. Y TECNOLOGIA "DR. CESAR MILSTEIN"
Articulos(IHEM)
Articulos de INST. HISTOLOGIA Y EMBRIOLOGIA DE MEND DR.M.BURGOS
Articulos de INST. HISTOLOGIA Y EMBRIOLOGIA DE MEND DR.M.BURGOS
Citación
Bellera, Carolina Leticia; Sbaraglini, Maria Laura; Balcazar, Dario Emmanuel; Fraccaroli, Laura Virginia; Vanrell, Maria Cristina; et al.; High-throughput Drug Repositioning for the Discovery of New Treatments for Chagas Disease; Bentham Science Publishers; Mini-reviews In Medicinal Chemistry; 15; 3; 3-2015; 182-193
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