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dc.contributor.author
Talarico, Laura Beatriz
dc.contributor.author
Byrne, Alana Brooke
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Amarilla, Sara
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Lovera, Dolores
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Vázquez, Cynthia
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Chamorro, Gustavo
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Acosta, Patricio Leandro
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Ferretti, Adrián
dc.contributor.author
Caballero, Mauricio Tomás
dc.contributor.author
Arbo, Antonio
dc.contributor.author
Polack, Fernando Pedro
dc.date.available
2018-04-09T17:35:41Z
dc.date.issued
2017-10
dc.identifier.citation
Talarico, Laura Beatriz; Byrne, Alana Brooke; Amarilla, Sara; Lovera, Dolores; Vázquez, Cynthia; et al.; Characterization of Type I Interferon Responses in Dengue and Severe Dengue in Children in Paraguay; Elsevier Science; Journal of Clinical Virology; 97; 10-2017; 10-17
dc.identifier.issn
1386-6532
dc.identifier.uri
http://hdl.handle.net/11336/41340
dc.description.abstract
Background: Infection with dengue virus (DENV) produces a wide spectrum of clinical illness ranging from asymptomatic infection to mild febrile illness, and to severe forms of the disease. Type I interferons (IFNs) represent an initial and essential host defense response against viruses. DENV has been reported to trigger a robust type I IFN response; however, IFN-α/β profile in the progression of disease is not well characterized.Objectives and study design: In this context, we conducted a retrospective study assessing the circulating serum levels of type I IFNs and related cytokines at different phases of illness in children during the 2011 outbreak of DENV in Paraguay. Demographic, clinical, laboratory and virological data were analyzed.Results: During defervescence, significantly higher levels of IFN-β, IL-6 and MIP-1β, were detected in severe vs. non-severe dengue patients. Additionally, a significant positive correlation between INF-α and viremia was detected in children with severe dengue. Significant positive correlations were also observed between IFN-β serum levels and hematocrit/hemoglobin during the febrile phase, whereas IFN-α levels negatively correlated with white blood cells during defervescence in severe dengue patients. Furthermore, previous serologic status of patients to DENV did not influence type I IFN production.Conclusions: The distinct type I IFN profile in children with dengue and severe dengue, as well as its association with viral load, cytokine production and laboratory manifestations indicate differences in innate and adaptive immune responses that should be investigated further in order to unveil the association of immunological and physiological pathways that underlie in DENV infection.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Science
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Interpheron Type I
dc.subject
Interpheron Alpha
dc.subject
Dengue
dc.subject.classification
Inmunología
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Characterization of Type I Interferon Responses in Dengue and Severe Dengue in Children in Paraguay
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-04-06T13:52:48Z
dc.journal.volume
97
dc.journal.pagination
10-17
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Talarico, Laura Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Investigación en Infectología Infantil; Argentina
dc.description.fil
Fil: Byrne, Alana Brooke. Fundación para la Investigación en Infectología Infantil; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
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Fil: Amarilla, Sara. Instituto de Medicina Tropical; Paraguay. Universidad Nacional de Asunción; Paraguay
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Fil: Lovera, Dolores. Universidad Nacional de Asunción; Paraguay. Instituto de Medicina Tropical; Paraguay
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Fil: Vázquez, Cynthia. Laboratorio Central de Salud Pública; Paraguay
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Fil: Chamorro, Gustavo. Laboratorio Central de Salud Pública; Paraguay
dc.description.fil
Fil: Acosta, Patricio Leandro. Fundación para la Investigación en Infectología Infantil; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Ferretti, Adrián. Fundación para la Investigación en Infectología Infantil; Argentina
dc.description.fil
Fil: Caballero, Mauricio Tomás. Fundación para la Investigación en Infectología Infantil; Argentina
dc.description.fil
Fil: Arbo, Antonio. Instituto de Medicina Tropical; Paraguay. Universidad Nacional de Asunción; Paraguay
dc.description.fil
Fil: Polack, Fernando Pedro. Fundación para la Investigación en Infectología Infantil; Argentina
dc.journal.title
Journal of Clinical Virology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.journalofclinicalvirology.com/article/S1386-6532(17)30286-X/fulltext
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.jcv.2017.10.010
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