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dc.contributor.author
Brossas, Jean Yves
dc.contributor.author
Gulin, Julián Ernesto Nicolás
dc.contributor.author
Bisio, Margarita María Catalina
dc.contributor.author
Chapelle, Manuel
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Marinach Patrice, Carine
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Bordessoulles, Mallaury
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Palazon Ruiz, George
dc.contributor.author
Vion, Jeremy
dc.contributor.author
Paris, Luc
dc.contributor.author
Altcheh, Jaime Marcelo
dc.contributor.author
Mazier, Dominique
dc.date.available
2018-04-09T17:14:00Z
dc.date.issued
2017-10
dc.identifier.citation
Brossas, Jean Yves; Gulin, Julián Ernesto Nicolás; Bisio, Margarita María Catalina; Chapelle, Manuel; Marinach Patrice, Carine; et al.; Secretome analysis of Trypanosoma cruzi by proteomics studies; Public Library of Science; Plos One; 12; 10; 10-2017; 1-66; e0185504
dc.identifier.issn
1932-6203
dc.identifier.uri
http://hdl.handle.net/11336/41332
dc.description.abstract
Background: Chagas disease is a debilitating often fatal disease resulting from infection by the protozoan parasite Trypanosoma cruzi. Chagas disease is endemic in 21 countries of the Americas, and it is an emerging disease in other countries as a result of migration. Given the chronic nature of the infection where intracellular parasites persist for years, the diagnosis of T. cruzi by direct detection is difficult, whereas serologic tests though sensitive may yield false-positive results. The development of new rapid test based on the identification of soluble parasitic antigens in serum would be a real innovation in the diagnosis of Chagas disease. Methods: To identify new soluble biomarkers that may improve diagnostic tests, we investigated the proteins secreted by T. cruzi using mass spectrometric analyses of conditioned culture media devoid of serum collected during the emergence of trypomastigotes from infected Vero cells. In addition, we compared the secretomes of two T. cruzi strains from DTU Tc VI (VD and CL Brener). Results: Analysis of the secretome collected during the emergence of trypomastigotes from Vero cells led to the identification of 591 T. cruzi proteins. Three hundred sixty three proteins are common to both strains and most belong to different multigenic super families (i.e. TcS, GP63, MASP, and DGF1). Ultimately we have established a list of 94 secreted proteins, common to both DTU Tc VI strains that do not belong to members of multigene families. Conclusions: This study provides the first comparative analysis of the secretomes from two distinct T. cruzi strains of DTU TcVI. This led us to identify a subset of common secreted proteins that could potentially serve as serum markers for T. cruzi infection. Their potential could now be evaluated, with specific antibodies using sera collected from patients and residents from endemic regions.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Public Library of Science
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Trypanosoma Cruzi
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Parasitic Disease
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Trypomastigotes
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Chagas Disease
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Vero Cells
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Host Cells
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Serum Proteins
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Heat Shock Response
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Parasitología
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Ciencias de la Salud
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CIENCIAS MÉDICAS Y DE LA SALUD
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Tecnologías que involucran la identificación de ADN, proteínas y enzimas, y cómo influyen en el conjunto de enfermedades y mantenimiento del bienestar
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Biotecnología de la Salud
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CIENCIAS MÉDICAS Y DE LA SALUD
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Bioquímica y Biología Molecular
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Secretome analysis of Trypanosoma cruzi by proteomics studies
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-04-06T13:56:29Z
dc.journal.volume
12
dc.journal.number
10
dc.journal.pagination
1-66; e0185504
dc.journal.pais
Estados Unidos
dc.journal.ciudad
San Francisco
dc.description.fil
Fil: Brossas, Jean Yves. Inserm; Francia. Universite de Paris VI; Francia. Hôpital Pitié-Salpêtrière; Francia
dc.description.fil
Fil: Gulin, Julián Ernesto Nicolás. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; Argentina. Gobierno de la Ciudad de Buenos Aires. Instituto Multidisciplinario de Investigaciones en Patologías Pediátricas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto Multidisciplinario de Investigaciones en Patologías Pediátricas.; Argentina
dc.description.fil
Fil: Bisio, Margarita María Catalina. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; Argentina. Gobierno de la Ciudad de Buenos Aires. Instituto Multidisciplinario de Investigaciones en Patologías Pediátricas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto Multidisciplinario de Investigaciones en Patologías Pediátricas.; Argentina
dc.description.fil
Fil: Chapelle, Manuel. Bruker Daltonics; Francia
dc.description.fil
Fil: Marinach Patrice, Carine. Inserm; Francia. Universite de Paris VI; Francia
dc.description.fil
Fil: Bordessoulles, Mallaury. Universite de Paris VI; Francia. Inserm; Francia
dc.description.fil
Fil: Palazon Ruiz, George. Inserm; Francia
dc.description.fil
Fil: Vion, Jeremy. Inserm; Francia
dc.description.fil
Fil: Paris, Luc. Hôpital Pitié-Salpêtrière; Francia. Universite de Paris VI; Francia
dc.description.fil
Fil: Altcheh, Jaime Marcelo. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; Argentina. Gobierno de la Ciudad de Buenos Aires. Instituto Multidisciplinario de Investigaciones en Patologías Pediátricas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto Multidisciplinario de Investigaciones en Patologías Pediátricas.; Argentina
dc.description.fil
Fil: Mazier, Dominique. Inserm; Francia. Universite de Paris VI; Francia. Hôpital Pitié-Salpêtrière; Francia
dc.journal.title
Plos One
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/org/10.1371/journal.pone.0185504
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0185504
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