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dc.contributor.author
Mazaira, Gisela Ileana
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dc.contributor.author
Lagadari, Mariana
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dc.contributor.author
Elerjman, Alejandra G.
dc.contributor.author
Galigniana, Mario Daniel
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dc.date.available
2016-02-11T13:10:29Z
dc.date.issued
2015-03-31
dc.identifier.citation
Mazaira, Gisela Ileana; Lagadari, Mariana; Elerjman, Alejandra G.; Galigniana, Mario Daniel; Molecular chaperones shape steroid receptor action and pharmacologic strategies; Jacobs Publisher; Jacobs Journal of Cell and Molecular Biology; 1; 1; 31-3-2015; 1-4
dc.identifier.issn
1306-0961
dc.identifier.uri
http://hdl.handle.net/11336/4125
dc.description.abstract
Chaperone oligomers exist in cell cytosols as preassembled heterocomplexes that function as protein-folding molecular machines able to assemble essential proteins related to families that embrace steroid receptors, protein-kinases, ubiquitin-ligases, and transcription factors, among other families of key proteins. Actually, steroid receptors may be considered a particular subset of transcription factors that can be activated by specific ligands. Some of them are primarily located in the cytoplasm, others are constitutively nuclear, but regardless of their subcellular distribution, they are constantly shuttling between both compartments in a highly dynamic manner. The chaperone heterocomplex associated to steroid receptors is not only involved in the stabilization of their conformation preventing their degradation by the proteasome, but it is also critical for the molecular mechanism of transport of these receptors and their subnuclear redistribution. In this article we summarized some of the general properties of molecular chaperones, in particular those belonging to a subfamily that is highly inducible by thermal shock, the heat-shock proteins, and review the most recent findings performed in the field of soluble protein trafficking, where molecular chaperones play a critical role.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Jacobs Publisher
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc/2.5/ar/
dc.subject
Steroid Receptor
dc.subject
Hsp90
dc.subject
Immunophilins
dc.subject
Fkbp52
dc.subject.classification
Bioquímica y Biología Molecular
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Molecular chaperones shape steroid receptor action and pharmacologic strategies
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-03-30 10:35:44.97925-03
dc.identifier.eissn
2381-2761
dc.journal.volume
1
dc.journal.number
1
dc.journal.pagination
1-4
dc.journal.pais
Estados Unidos
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dc.journal.ciudad
Texas
dc.description.fil
Fil: Mazaira, Gisela Ileana. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina
dc.description.fil
Fil: Lagadari, Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
dc.description.fil
Fil: Elerjman, Alejandra G.. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina
dc.description.fil
Fil: Galigniana, Mario Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina
dc.journal.title
Jacobs Journal of Cell and Molecular Biology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.jacobspublishers.com/index.php/j-j-cell-mol-bio-1-1-004
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/issn/1306-0961
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