Artículo
CD169 + macrophages orchestrate innate immune responses by regulating bacterial localization in the spleen
Perez, Oriana A.; Yeung, Stephen T.; Vera Licona, Paola; Romagnoli, Pablo Alberto
; Samji, Tasleem; Ural, Basak B.; Maher, Leigh; Tanaka, Masato; Khanna, Kamal M.
Fecha de publicación:
10/2017
Editorial:
American Association for the Advancement of Science
Revista:
Science Immunology
ISSN:
2470-9468
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
The spleen is an important site for generating protective immune responses against pathogens. After infection, immune cells undergo rapid reorganization to initiate and maintain localized inflammatory responses; however, the mechanisms governing this spatial and temporal cellular reorganization remain unclear. We show that the strategic position of splenic marginal zone CD169+ macrophages is vital for rapid initiation of antibacterial responses. In addition to controlling initial bacterial growth, CD169+ macrophages orchestrate a second phase of innate protection by mediating the transport of bacteria to splenic T cell zones. This compartmentalization of bacteria within the spleen was essential for driving the reorganization of innate immune cells into hierarchical clusters and for local interferon-γ production near sites of bacterial replication foci. Our results show that both phases of the antimicrobial innate immune response were dependent on CD169+ macrophages, and, in their absence, the series of events needed for pathogen clearance and subsequent survival of the host was disrupted. Our study provides insight into how lymphoid organ structure and function are related at a fundamental level.
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Articulos(SEDE CENTRAL)
Articulos de SEDE CENTRAL
Articulos de SEDE CENTRAL
Citación
Perez, Oriana A.; Yeung, Stephen T.; Vera Licona, Paola; Romagnoli, Pablo Alberto; Samji, Tasleem; et al.; CD169 + macrophages orchestrate innate immune responses by regulating bacterial localization in the spleen; American Association for the Advancement of Science; Science Immunology; 2; 16; 10-2017
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