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dc.contributor.author
Quintana, María Agustina
dc.contributor.author
Mozer Sciani, Juliana
dc.contributor.author
Vatti Auada, Aline Vivian
dc.contributor.author
Martínez, María Mercedes
dc.contributor.author
Sanchez, Matias Nicolas
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dc.contributor.author
Santoro, Marcelo Larami
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dc.contributor.author
Fan, Hui Wen
dc.contributor.author
Peichoto, María Elisa
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dc.date.available
2018-04-06T19:09:27Z
dc.date.issued
2017-11
dc.identifier.citation
Quintana, María Agustina; Mozer Sciani, Juliana; Vatti Auada, Aline Vivian; Martínez, María Mercedes; Sanchez, Matias Nicolas; et al.; Stinging caterpillars from the genera Podalia , Leucanella and Lonomia in Misiones, Argentina: A preliminary comparative approach to understand their toxicity; Elsevier Science Inc; Comparative Biochemistry And Physiology. Toxicology & Pharmacology; 202; 11-2017; 55-62
dc.identifier.issn
1532-0456
dc.identifier.uri
http://hdl.handle.net/11336/41213
dc.description.abstract
Dermal contact with Lepidoptera specimens at their larval stage (caterpillar) may cause systemic and/or local envenomation. There are multiple venomous species of them in Argentina, but their overall venom composition is poorly known. Lately, several cases of envenomation have been reported in the Misiones province, Northeastern Argentina. Thus, this work aimed to compare the protein composition, and the enzymatic properties of bristle extracts from caterpillars belonging to the families Megalopygidae (Podalia ca. fuscescens) and Saturniidae (Leucanella memusae and Lonomia obliqua) - the most common causative agents of accidents in Misiones -, and additionally to test their cross-reactivity with the L. obliqua antivenom produced in Brazil. Saturniidae venoms exhibited striking similarity in both their electrophoretic protein profile, and antigenic cross-reactivity. All venoms degraded azocasein ? with the highest proteolytic activity observed in the P. ca. fuscescens bristle extract ?, and hyaluronic acid, but the latter at low levels. Lonomia obliqua venom exhibited the highest level of phospholipase A2 activity. Bristle extracts from P. ca. fuscescens and L. obliqua both degraded human fibrin(ogen) and shortened the clotting time triggered by calcium, while L. memusae venom inhibited plasma coagulation. Proteins related to the coagulation disturbance were identified by mass spectrometry in all samples. Altogether, our findings show for the first time a comparative biotoxinological analysis of three genera of caterpillars with medical relevance. Moreover, this study provides relevant information about the pathophysiological mechanisms whereby these caterpillar bristle extracts can induce toxicity on human beings, and gives insight into future directions for research on them.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Science Inc
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Caterpillars
dc.subject
Coagulation
dc.subject
Hemostasis
dc.subject
Lonomia Antivenom
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Megalopygidae
dc.subject
Saturniidae
dc.subject
South America
dc.subject
Spines
dc.subject
Venoms
dc.subject.classification
Otras Ciencias Biológicas
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Stinging caterpillars from the genera Podalia , Leucanella and Lonomia in Misiones, Argentina: A preliminary comparative approach to understand their toxicity
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-04-04T14:34:18Z
dc.identifier.eissn
1532-0456
dc.journal.volume
202
dc.journal.pagination
55-62
dc.journal.pais
Países Bajos
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dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Quintana, María Agustina. Ministerio de Salud. Instituto Nacional de Medicina Tropical; Argentina
dc.description.fil
Fil: Mozer Sciani, Juliana. Governo Do Estado de Sao Paulo. Secretaria Da Saude. Instituto Butantan; Brasil
dc.description.fil
Fil: Vatti Auada, Aline Vivian. Governo Do Estado de Sao Paulo. Secretaria Da Saude. Instituto Butantan; Brasil
dc.description.fil
Fil: Martínez, María Mercedes. Ministerio de Salud. Instituto Nacional de Medicina Tropical; Argentina
dc.description.fil
Fil: Sanchez, Matias Nicolas. Ministerio de Salud. Instituto Nacional de Medicina Tropical; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Santoro, Marcelo Larami. Governo Do Estado de Sao Paulo. Secretaria Da Saude. Instituto Butantan; Brasil
dc.description.fil
Fil: Fan, Hui Wen. Ministerio de Salud. Instituto Nacional de Medicina Tropical; Argentina
dc.description.fil
Fil: Peichoto, María Elisa. Ministerio de Salud. Instituto Nacional de Medicina Tropical; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.journal.title
Comparative Biochemistry And Physiology. Toxicology & Pharmacology
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1016/j.cbpc.2017.07.007
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1532045617301382
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