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dc.contributor.author
Gay, Claudia Carolina
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dc.contributor.author
Sanz, Libia
dc.contributor.author
Calvete, Juan J.
dc.contributor.author
Pla, Davinia
dc.date.available
2018-04-06T17:21:42Z
dc.date.issued
2015-12
dc.identifier.citation
Gay, Claudia Carolina; Sanz, Libia; Calvete, Juan J.; Pla, Davinia; Snake Venomics and Antivenomics of Bothrops diporus, a Medically Important Pitviper in Northeastern Argentina; MDPI; Toxins; 8; 1; 12-2015; 1-13
dc.identifier.issn
2072-6651
dc.identifier.uri
http://hdl.handle.net/11336/41152
dc.description.abstract
Snake species within genus Bothrops are responsible for more than 80% of the snakebites occurring in South America. The species that cause most envenomings in Argentina, B. diporus, is widely distributed throughout the country, but principally found in the Northeast, the region with the highest rates of snakebites. The venom proteome of this medically relevant snake was unveiled using a venomic approach. It comprises toxins belonging to fourteen protein families,be ing dominated by PI- and PIII-SVMPs, PLA2 molecules, BPP-like peptides, L-amino acid oxidase and serine proteinases. This toxin profile largely explains the characteristic pathophysiological effects of bothropic snakebites observed in patients envenomed by B. diporus. Antivenomic analysis of the SAB antivenom (Instituto Vital Brazil) against the venom of B. diporus showed that this pentabothropic antivenom efficiently recognized all the venom proteins and exhibited poor affinity towards the small peptide (BPPs and tripeptide inhibitors of PIII-SVMPs) components of the venom.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
MDPI
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Bothrops Diporus Venom
dc.subject
Venomics
dc.subject
Snake Venom Proteome
dc.subject
Antivenomics
dc.subject
Mass Spectrometry
dc.subject.classification
Otras Ciencias Biológicas
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Snake Venomics and Antivenomics of Bothrops diporus, a Medically Important Pitviper in Northeastern Argentina
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-03-28T14:14:16Z
dc.identifier.eissn
2072-6651
dc.journal.volume
8
dc.journal.number
1
dc.journal.pagination
1-13
dc.journal.pais
Bahamas
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dc.journal.ciudad
Basil
dc.description.fil
Fil: Gay, Claudia Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste. Instituto de Química Básica y Aplicada del Nordeste Argentino. Universidad Nacional del Nordeste. Facultad de Ciencias Exactas Naturales y Agrimensura. Instituto de Química Básica y Aplicada del Nordeste Argentino; Argentina
dc.description.fil
Fil: Sanz, Libia. Instituto de Biomedicina de Valencia; España
dc.description.fil
Fil: Calvete, Juan J.. Instituto de Biomedicina de Valencia; España
dc.description.fil
Fil: Pla, Davinia. Instituto de Biomedicina de Valencia; España
dc.journal.title
Toxins
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3390/toxins8010009
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728531/
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