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dc.contributor.author
Angiolella, Letizia
dc.contributor.author
Carradori, Simone
dc.contributor.author
Maccallini, Cristina
dc.contributor.author
Giusiano, Gustavo Emilio
dc.contributor.author
Supuran, Claudiu T.
dc.date.available
2018-04-06T13:03:47Z
dc.date.issued
2017-04
dc.identifier.citation
Angiolella, Letizia; Carradori, Simone; Maccallini, Cristina; Giusiano, Gustavo Emilio; Supuran, Claudiu T.; Targeting Malassezia species for novel synthetic and natural antidandruff agents; Bentham Science Publishers; Current Medicinal Chemistry; 24; 22; 4-2017; 2392-2412
dc.identifier.issn
0929-8673
dc.identifier.uri
http://hdl.handle.net/11336/41045
dc.description.abstract
Malassezia spp. are lipophilic yeasts not only present in the normal skin microflora, but also responsible of skin-related diseases (pityriasis versicolor, seborrheic/atopic dermatitis and dandruff) as well as systemic fungal infections in humans and animals. Their treatment and eradication are mainly based on old azole drugs, which are characterized by poor compliance, unpredictable clinical efficacy, emerging resistance and several side effects. These drawbacks have prompted the research toward novel synthetic and natural derivatives/ nanomaterials targeting other pivotal enzymes/pathways such as carbonic anhydrase (MgCA) and lipases, alone or in combination, in order to improve the eradication rate of this fungus. This review accomplished an update on this important topic dealing with the latest discoveries of synthetic scaffolds and natural products for the treatment of Malassezia spp.-related diseases, thus suggesting new opportunities to design innovative and alternative anti-dandruff drugs.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Bentham Science Publishers
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Azoles
dc.subject
Carbonic Anhydrase Inhibitors
dc.subject
Lipase Inhibitors
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Malassezia
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Otras Ciencias Biológicas
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Targeting Malassezia species for novel synthetic and natural antidandruff agents
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-04-04T14:33:45Z
dc.journal.volume
24
dc.journal.number
22
dc.journal.pagination
2392-2412
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Oak Park
dc.description.fil
Fil: Angiolella, Letizia. Sapienza University of Rome; Italia. Instituto de Investigaciones Universitarias Roma la Sapienza; Italia
dc.description.fil
Fil: Carradori, Simone. University of Chieti-Pescara; Italia
dc.description.fil
Fil: Maccallini, Cristina. University of Chieti-Pescara; Italia
dc.description.fil
Fil: Giusiano, Gustavo Emilio. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Nordeste. Instituto de Medicina Regional. Departamento de Medicina Tropical; Argentina
dc.description.fil
Fil: Supuran, Claudiu T.. Universita Degli Studi Di Firenze; Italia
dc.journal.title
Current Medicinal Chemistry
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.2174/0929867324666170404110631
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.eurekaselect.com/151310/article


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