Artículo
Diazepam treatment reduces inflammatory cells and mediators in the central nervous system of rats with experimental autoimmune encephalomyelitis
Fernández Hurst, Nicolás
; Zanetti, Samanta Romina
; Baez, Natalia Soledad
; Bibolini, Mario Javier
; Bouzat, Cecilia Beatriz
; Roth, German Alfredo
Fecha de publicación:
12/2017
Editorial:
Elsevier Science
Revista:
Journal of Neuroimmunology
ISSN:
0165-5728
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Benzodiazepines are psychoactive drugs and some of them also affect immune cells. We here characterized the inflammatory and infiltrating immune cells in the central nervous system (CNS) during the acute phase of experimental autoimmune encephalomyelitis (EAE) in animals treated with Diazepam. Also, we evaluated the expression of Translocator Protein (18kDa) (TSPO), which is a biomarker of neuroinflammatory diseases. The results indicate that Diazepam exerts protective effects on EAE development, decreasing the incidence of the disease and reducing the number of inflammatory cells in CNS, with a concomitant decrease of TSPO levels in brain tissue and CNS inflammatory CD11b+ cells.
Palabras clave:
Autoimmunity
,
Diazepam
,
Inflammatory T Cells
,
Tspo
Archivos asociados
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Identificadores
Colecciones
Articulos(CIBICI)
Articulos de CENTRO DE INV.EN BIOQUI.CLINICA E INMUNOLOGIA
Articulos de CENTRO DE INV.EN BIOQUI.CLINICA E INMUNOLOGIA
Articulos(CIQUIBIC)
Articulos de CENTRO DE INVEST.EN QCA.BIOL.DE CORDOBA (P)
Articulos de CENTRO DE INVEST.EN QCA.BIOL.DE CORDOBA (P)
Articulos(INIBIBB)
Articulos de INST.DE INVEST.BIOQUIMICAS BAHIA BLANCA (I)
Articulos de INST.DE INVEST.BIOQUIMICAS BAHIA BLANCA (I)
Citación
Fernández Hurst, Nicolás; Zanetti, Samanta Romina; Baez, Natalia Soledad; Bibolini, Mario Javier; Bouzat, Cecilia Beatriz; et al.; Diazepam treatment reduces inflammatory cells and mediators in the central nervous system of rats with experimental autoimmune encephalomyelitis; Elsevier Science; Journal of Neuroimmunology; 313; 12-2017; 145-151
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