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dc.contributor.author
Morris Hanon, Olivia
dc.contributor.author
Furmento, Verónica Alejandra
dc.contributor.author
Rodríguez Varela, Maria Soledad
dc.contributor.author
Mucci, Sofia
dc.contributor.author
Fernandez Espinosa, Damian Dario
dc.contributor.author
Romorini, Leonardo
dc.contributor.author
Sevlever, Gustavo Emilio
dc.contributor.author
Scassa, Maria Elida
dc.contributor.author
Videla Richardson, Guillermo Agustín
dc.date.available
2018-04-05T17:16:15Z
dc.date.issued
2017-07
dc.identifier.citation
Morris Hanon, Olivia; Furmento, Verónica Alejandra; Rodríguez Varela, Maria Soledad; Mucci, Sofia; Fernandez Espinosa, Damian Dario; et al.; The Cell Cycle Inhibitors p21 Cip1 and p27 Kip1 Control Proliferation but Enhance DNA Damage Resistance of Glioma Stem Cells; Elsevier; Neoplasia; 19; 7; 7-2017; 519-529
dc.identifier.issn
1476-5586
dc.identifier.uri
http://hdl.handle.net/11336/40898
dc.description.abstract
High-grade gliomas are the most prevalent and lethal primary brain tumors. They display a hierarchical arrangement with a population of self-renewing and highly tumorigenic cells called cancer stemcells. These cells are thought to be responsible for tumor recurrence, which make them main candidates for targeted therapies. Unbridled cell cycle progression may explain the selective sensitivity of some cancer cells to treatments. The members of the Cip/Kip family p21Cip1 and p27Kip1 were initially considered as tumor suppressors based on their ability to block proliferation. However, they are currently looked at as proteins with dual roles in cancer: one as tumor suppressor and the other asoncogene. Therefore, the aimof this study was to determine the functions of these cell cycle inhibitors in five patientderived glioma stem cell?enriched cell lines. We found that these proteins are functional in glioma stem cells. They negatively regulate cell cycle progression both in unstressed conditions and in response to genotoxic stress. In addition, p27Kip1 is upregulated in nutrient-restricted and differentiating cells, suggesting that this Cip/Kip is a mediator of antimitogenic signals in glioma cells. Importantly, the lack of these proteins impairs cell cycle halt in response togenotoxic agents, rendering cells more vulnerable to DNA damage. For these reasons, these proteins may operate both as tumor suppressors, limiting cell proliferation, and as oncogenes, conferring cell resistance to DNA damage.Thus, deepening our knowledge on the biological functions of these Cip/Kipsmay shed light on howsomecancer cells develop drug resistance.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
Glioma Stem Cells
dc.subject
Dna Damage
dc.subject
Cell Cycle
dc.subject
Cip/Kip
dc.subject.classification
Otras Medicina Básica
dc.subject.classification
Medicina Básica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
The Cell Cycle Inhibitors p21 Cip1 and p27 Kip1 Control Proliferation but Enhance DNA Damage Resistance of Glioma Stem Cells
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-04-05T13:42:18Z
dc.journal.volume
19
dc.journal.number
7
dc.journal.pagination
519-529
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Nueva York
dc.description.fil
Fil: Morris Hanon, Olivia. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
dc.description.fil
Fil: Furmento, Verónica Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
dc.description.fil
Fil: Rodríguez Varela, Maria Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
dc.description.fil
Fil: Mucci, Sofia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Fernandez Espinosa, Damian Dario. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
dc.description.fil
Fil: Romorini, Leonardo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
dc.description.fil
Fil: Sevlever, Gustavo Emilio. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
dc.description.fil
Fil: Scassa, Maria Elida. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
dc.description.fil
Fil: Videla Richardson, Guillermo Agustín. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
dc.journal.title
Neoplasia
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.neo.2017.04.001
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5458648/
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.neoplasia.com/article/S1476-5586(17)30044-1/fulltext
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