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dc.contributor.author
Friend, Danielle M.
dc.contributor.author
Devarakonda, Kavya
dc.contributor.author
O'Neal, Timothy J.
dc.contributor.author
Skirzewski, Miguel
dc.contributor.author
Papageorgiou, Ioannis
dc.contributor.author
Kaplan, Alanna R.
dc.contributor.author
Liow, Jeih San
dc.contributor.author
Guo, Juen
dc.contributor.author
Rane, Sushil G.
dc.contributor.author
Rubinstein, Marcelo
dc.contributor.author
Alvarez, Verónica A.
dc.contributor.author
Hall, Kevin D.
dc.contributor.author
Kravitz, Alexxai V.
dc.date.available
2018-04-05T14:52:02Z
dc.date.issued
2017-02
dc.identifier.citation
Friend, Danielle M.; Devarakonda, Kavya; O'Neal, Timothy J.; Skirzewski, Miguel; Papageorgiou, Ioannis; et al.; Basal Ganglia Dysfunction Contributes to Physical Inactivity in Obesity; Cell Press; Cell Metabolism; 25; 2; 2-2017; 312-321
dc.identifier.issn
1550-4131
dc.identifier.uri
http://hdl.handle.net/11336/40852
dc.description.abstract
Obesity is associated with physical inactivity, which exacerbates the health consequences of weight gain. However, the mechanisms that mediate this association are unknown. We hypothesized that deficits in dopamine signaling contribute to physical inactivity in obesity. To investigate this, we quantified multiple aspects of dopamine signaling in lean and obese mice. We found that D2-type receptor (D2R) binding in the striatum, but not D1-type receptor binding or dopamine levels, was reduced in obese mice. Genetically removing D2Rs from striatal medium spiny neurons was sufficient to reduce motor activity in lean mice, whereas restoring Gi signaling in these neurons increased activity in obese mice. Surprisingly, although mice with low D2Rs were less active, they were not more vulnerable to diet-induced weight gain than control mice. We conclude that deficits in striatal D2R signaling contribute to physical inactivity in obesity, but inactivity is more a consequence than a cause of obesity.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Cell Press
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
D2
dc.subject
Dopamine
dc.subject
Exercise
dc.subject
Obese
dc.subject
Obesity
dc.subject
Physical Activity
dc.subject
Striatum
dc.subject
Weight Loss
dc.subject.classification
Otras Ciencias Biológicas
dc.subject.classification
Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Basal Ganglia Dysfunction Contributes to Physical Inactivity in Obesity
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-04-04T14:19:47Z
dc.journal.volume
25
dc.journal.number
2
dc.journal.pagination
312-321
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Cambridge
dc.description.fil
Fil: Friend, Danielle M.. National Institutes of Health; Estados Unidos
dc.description.fil
Fil: Devarakonda, Kavya. National Institutes of Health; Estados Unidos
dc.description.fil
Fil: O'Neal, Timothy J.. National Institutes of Health; Estados Unidos
dc.description.fil
Fil: Skirzewski, Miguel. National Institutes of Health; Estados Unidos
dc.description.fil
Fil: Papageorgiou, Ioannis. National Institutes of Health; Estados Unidos
dc.description.fil
Fil: Kaplan, Alanna R.. National Institutes of Health; Estados Unidos
dc.description.fil
Fil: Liow, Jeih San. National Institutes of Health; Estados Unidos
dc.description.fil
Fil: Guo, Juen. National Institutes of Health; Estados Unidos
dc.description.fil
Fil: Rane, Sushil G.. National Institutes of Health; Estados Unidos
dc.description.fil
Fil: Rubinstein, Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Fisiología, Biología Molecular y Celular; Argentina. University of Michigan; Estados Unidos
dc.description.fil
Fil: Alvarez, Verónica A.. National Institutes of Health; Estados Unidos
dc.description.fil
Fil: Hall, Kevin D.. National Institutes of Health; Estados Unidos
dc.description.fil
Fil: Kravitz, Alexxai V.. National Institutes of Health; Estados Unidos
dc.journal.title
Cell Metabolism
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.cmet.2016.12.001
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.cell.com/cell-metabolism/fulltext/S1550-4131(16)30596-4


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