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dc.contributor.author
Lotfipour, Shahrdad
dc.contributor.author
Mojica, Celina
dc.contributor.author
Nakauchi, Sakura
dc.contributor.author
Lipovsek, Maria Marcela
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dc.contributor.author
Silverstein, Sarah
dc.contributor.author
Cushman, Jesse
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Tirtorahardjo, James
dc.contributor.author
Poulos, Andrew
dc.contributor.author
Elgoyhen, Ana Belen
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dc.contributor.author
Sumikawa, Katumi
dc.contributor.author
Fanselow, Michael S.
dc.contributor.author
Boulter, Jim
dc.date.available
2018-04-04T17:04:12Z
dc.date.issued
2017-05
dc.identifier.citation
Lotfipour, Shahrdad; Mojica, Celina; Nakauchi, Sakura; Lipovsek, Maria Marcela; Silverstein, Sarah; et al.; α2* Nicotinic acetylcholine receptors influence hippocampus-dependent learning and memory in adolescent mice; Cold Spring Harbor Laboratory Press; Learning & Memory; 24; 6; 5-2017; 231-244
dc.identifier.issn
1549-5485
dc.identifier.uri
http://hdl.handle.net/11336/40714
dc.description.abstract
The absence of α2* nicotinic acetylcholine receptors (nAChRs) in oriens lacunosum moleculare (OLM) GABAergic interneurons ablate the facilitation of nicotine-induced hippocampal CA1 long-term potentiation and impair memory. The current study delineated whether genetic mutations of α2* nAChRs (Chrna2L9′S/L9′S and Chrna2KO) influence hippocampus-dependent learning and memory and CA1 synaptic plasticity. We substituted a serine for a leucine (L9′S) in the α2 subunit (encoded by the Chrna2 gene) to make a hypersensitive nAChR. Using a dorsal hippocampus-dependent task of preexposure-dependent contextual fear conditioning, adolescent hypersensitive Chrna2L9′S/L9′S male mice exhibited impaired learning and memory. The deficit was rescued by low-dose nicotine exposure. Electrophysiological studies demonstrated that hypersensitive α2 nAChRs potentiate acetylcholine-induced ion channel flux in oocytes and acute nicotine-induced facilitation of dorsal/intermediate CA1 hippocampal long-term potentiation in Chrna2L9′S/L9′S mice. Adolescent male mice null for the α2 nAChR subunit exhibited a baseline deficit in learning that was not reversed by an acute dose of nicotine. These effects were not influenced by locomotor, sensory or anxiety-related measures. Our results demonstrated that α2* nAChRs influenced hippocampus-dependent learning and memory, as well as nicotine-facilitated CA1 hippocampal synaptic plasticity.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Cold Spring Harbor Laboratory Press
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Receptores Nicotínicos
dc.subject
Canales Iónicosaddicción
dc.subject.classification
Otras Ciencias Biológicas
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
α2* Nicotinic acetylcholine receptors influence hippocampus-dependent learning and memory in adolescent mice
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-04-04T14:14:35Z
dc.identifier.eissn
1549-5417
dc.journal.volume
24
dc.journal.number
6
dc.journal.pagination
231-244
dc.journal.pais
Estados Unidos
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dc.journal.ciudad
Nueva York
dc.description.fil
Fil: Lotfipour, Shahrdad. University of California at Los Angeles; Estados Unidos
dc.description.fil
Fil: Mojica, Celina. University of California at Los Angeles; Estados Unidos
dc.description.fil
Fil: Nakauchi, Sakura. University of California at Irvine; Estados Unidos
dc.description.fil
Fil: Lipovsek, Maria Marcela. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular ; Argentina
dc.description.fil
Fil: Silverstein, Sarah. University of California at Los Angeles; Estados Unidos
dc.description.fil
Fil: Cushman, Jesse. University of California at Los Angeles; Estados Unidos
dc.description.fil
Fil: Tirtorahardjo, James. University of California at Irvine; Estados Unidos
dc.description.fil
Fil: Poulos, Andrew. University of California at Los Angeles; Estados Unidos. State University of New York; Estados Unidos
dc.description.fil
Fil: Elgoyhen, Ana Belen. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular ; Argentina
dc.description.fil
Fil: Sumikawa, Katumi. University of California at Irvine; Estados Unidos
dc.description.fil
Fil: Fanselow, Michael S.. University of California at Los Angeles; Estados Unidos
dc.description.fil
Fil: Boulter, Jim. University of California at Los Angeles; Estados Unidos
dc.journal.title
Learning & Memory
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://learnmem.cshlp.org/content/24/6/231
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://doi.org/10.1101/lm.045369.117
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