Mostrar el registro sencillo del ítem

dc.contributor.author
Agostino, Patricia  
dc.contributor.author
Gatto, Emilia Mabel  
dc.contributor.author
Cesarini, M.  
dc.contributor.author
Etcheverry, J.L.  
dc.contributor.author
Sanguinetti, A.  
dc.contributor.author
Golombek, Diego Andrés  
dc.date.available
2018-04-04T15:30:58Z  
dc.date.issued
2017-02  
dc.identifier.citation
Agostino, Patricia; Gatto, Emilia Mabel; Cesarini, M.; Etcheverry, J.L.; Sanguinetti, A.; et al.; Deficits in temporal processing correlate with clinical progression in Huntington's disease; Wiley Blackwell Publishing, Inc; Acta Neurologica Scandinavica; 136; 4; 2-2017; 1-8  
dc.identifier.issn
0001-6314  
dc.identifier.uri
http://hdl.handle.net/11336/40687  
dc.description.abstract
Objectives: Precise temporal performance is crucial for several complex tasks. Time estimation in the second-to-minutes range-known as interval timing-involves the interaction of the basal ganglia and the prefrontal cortex via dopaminergic-glutamatergic pathways. Patients with Huntington´s disease (HD) present deficits in cognitive and motor functions that require fine control of temporal processing. The objective of the present work was to assess temporal cognition through a peak-interval time (PI) production task in patients with HD and its potential correlation with the Unified Huntington´s Disease Rating Scale (UHDRS). Materials and methods: Patients with molecular diagnosis of HD and controls matched by age, sex and educational level (n=18/group) were tested for interval timing in short- (3 seconds), medium- (6 seconds) and long (12 seconds)-duration stimuli. Results: Significant differences were observed in the PI task, with worse performance in HD compared to controls. Patients underestimated real time (left-shifted Peak location) for 6- and 12-second intervals (P<.05) and presented decreased temporal precision for all the intervals evaluated (P<.01). Importantly, a significant correlation was found between time performance and the UHDRS (P<.01). Patients´ responses also deviated from the scalar property. Conclusions: Our results contribute to support that timing functions are impaired in HD in correlation with clinical deterioration. Recordings of cognitive performance related to timing could be a potential useful tool to measure the neurodegenerative progression of movement disorder-related pathologies.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Wiley Blackwell Publishing, Inc  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Dopamine  
dc.subject
Huntington'S Disease  
dc.subject
Medium Spiny Neurons  
dc.subject
Timing And Time Perception  
dc.subject.classification
Medicina Critica y de Emergencia  
dc.subject.classification
Medicina Clínica  
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
Deficits in temporal processing correlate with clinical progression in Huntington's disease  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2018-04-04T14:15:51Z  
dc.journal.volume
136  
dc.journal.number
4  
dc.journal.pagination
1-8  
dc.journal.pais
Reino Unido  
dc.journal.ciudad
Londres  
dc.description.fil
Fil: Agostino, Patricia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina  
dc.description.fil
Fil: Gatto, Emilia Mabel. Instituto de Neurociencias Buenos Aires S. A.; Argentina  
dc.description.fil
Fil: Cesarini, M.. Instituto de Neurociencias Buenos Aires S. A.; Argentina  
dc.description.fil
Fil: Etcheverry, J.L.. Instituto de Neurociencias Buenos Aires S. A.; Argentina  
dc.description.fil
Fil: Sanguinetti, A.. Instituto de Neurociencias Buenos Aires S. A.; Argentina  
dc.description.fil
Fil: Golombek, Diego Andrés. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina  
dc.journal.title
Acta Neurologica Scandinavica  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1111/ane.12728  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1111/ane.12728