Show simple item record

dc.contributor.author Orioli, Iêda M.
dc.contributor.author Dolk, Helen
dc.contributor.author López Camelo, Jorge Santiago
dc.contributor.author Mattos, Daniel
dc.contributor.author Poletta, Fernando Adrián
dc.contributor.author Dutra, Maria G.
dc.contributor.author Carvalho, Flavia M.
dc.contributor.author Castilla, Eduardo Enrique
dc.date.available 2018-04-03T23:09:39Z
dc.date.issued 2017-11
dc.identifier.citation Orioli, Iêda M.; Dolk, Helen; López Camelo, Jorge Santiago; Mattos, Daniel; Poletta, Fernando Adrián; et al.; Prevalence and clinical profile of microcephaly in South America pre-Zika, 2005-14: prevalence and case-control study; BMJ; BMJ; 359; 11-2017
dc.identifier.issn 1756-1833
dc.identifier.uri http://hdl.handle.net/11336/40641
dc.description.abstract Objective To describe the prevalence and clinical spectrum of microcephaly in South America for the period 2005-14, before the start of the Zika epidemic in 2015, as a baseline for future surveillance as the Zika epidemic spreads and as other infectious causes may emerge in future.Design Prevalence and case-control study.Data sources ECLAMC (Latin American Collaborative Study of Congenital Malformations) database derived from 107 hospitals in 10 South American countries, 2005 to 2014. Data on microcephaly cases, four non-malformed controls per case, and all hospital births (all births for hospital based prevalence, resident within municipality for population based prevalence). For 2010-14, head circumference data were available and compared with Intergrowth charts.Results 552 microcephaly cases were registered, giving a hospital based prevalence of 4.4 (95% confidence interval 4.1 to 4.9) per 10 000 births and a population based prevalence of 3.0 (2.7 to 3.4) per 10 000. Prevalence varied significantly between countries and between regions and hospitals within countries. Thirty two per cent (n=175) of cases were prenatally diagnosed; 29% (n=159) were perinatal deaths. Twenty three per cent (n=128) were associated with a diagnosed genetic syndrome, 34% (n=189) polymalformed without a syndrome diagnosis, 12% (n=65) with associated neural malformations, and 26% (n=145) microcephaly only. In addition, 3.8% (n=21) had a STORCH (syphilis, toxoplasmosis, other including HIV, rubella, cytomegalovirus, and herpes simplex) infection diagnosis and 2.0% (n=11) had consanguineous parents. Head circumference measurements available for 184/235 cases in 2010-14 showed 45% (n=82) more than 3 SD below the mean, 24% (n=44) between 3 SD and 2 SD below the mean, and 32% (n=58) larger than -2 SD.Conclusion Extrapolated to the nearly 7 million annual births in South America, an estimated 2000-2500 microcephaly cases were diagnosed among births each year before the Zika epidemic began in 2015. Clinicians are using more than simple metrics to make microcephaly diagnoses. Endemic infections are important enduring causes of microcephaly.
dc.format application/pdf
dc.language.iso eng
dc.publisher BMJ
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc/2.5/ar/
dc.subject MICROCEPHALY
dc.subject ZIKA VIRUS
dc.subject EPIDEMIOLOGY
dc.subject SOUTH AMERICA
dc.subject.classification Inmunología
dc.subject.classification Medicina Básica
dc.subject.classification CIENCIAS MÉDICAS Y DE LA SALUD
dc.title Prevalence and clinical profile of microcephaly in South America pre-Zika, 2005-14: prevalence and case-control study
dc.type info:eu-repo/semantics/article
dc.type info:ar-repo/semantics/artículo
dc.type info:eu-repo/semantics/publishedVersion
dc.date.updated 2018-03-27T20:00:53Z
dc.journal.volume 359
dc.journal.pais Reino Unido
dc.journal.ciudad Londres
dc.description.fil Fil: Orioli, Iêda M.. Instituto Nacional de Genética Médica Populacional; Brasil. Universidade Federal do Rio de Janeiro; Brasil
dc.description.fil Fil: Dolk, Helen. Ulster University; Reino Unido
dc.description.fil Fil: López Camelo, Jorge Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET.; Argentina. Instituto Nacional de Genética Médica Populacional; Brasil
dc.description.fil Fil: Mattos, Daniel. Instituto Nacional de Genética Médica Populacional; Brasil. Universidade Federal do Rio de Janeiro; Brasil
dc.description.fil Fil: Poletta, Fernando Adrián. Instituto Nacional de Genética Médica Populacional; Brasil. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET.; Argentina
dc.description.fil Fil: Dutra, Maria G.. Fundación Oswaldo Cruz; Brasil
dc.description.fil Fil: Carvalho, Flavia M.. Fundación Oswaldo Cruz; Brasil
dc.description.fil Fil: Castilla, Eduardo Enrique. Instituto Nacional de Genética Médica Populacional; Brasil. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET.; Argentina
dc.journal.title BMJ
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1136/bmj.j5018
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/https://www.bmj.com/content/359/bmj.j5018
dc.conicet.fuente Elsevier


Archivos asociados

This item appears in the following Collection(s)

Show simple item record

info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial 2.5 Unported (CC BY-NC 2.5)