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dc.contributor.author Maglietti, Felipe Horacio
dc.contributor.author Tellado, Matías Nicolás
dc.contributor.author Olaiz, Nahuel Manuel
dc.contributor.author Michinski, Sebastián Diego
dc.contributor.author Marshall, Guillermo Ricardo
dc.date.available 2018-04-03T22:15:47Z
dc.date.issued 2017-01
dc.identifier.citation Maglietti, Felipe Horacio; Tellado, Matías Nicolás; Olaiz, Nahuel Manuel; Michinski, Sebastián Diego; Marshall, Guillermo Ricardo; Minimally invasive electrochemotherapy procedure for treating nasal duct tumors in dogs using a single needle electrode; Association of Radiology and Oncology; Radiology and Oncology; 51; 4; 1-2017; 1-9
dc.identifier.uri http://hdl.handle.net/11336/40625
dc.description.abstract Background: Nasal cavity tumors are usually diagnosed late, when they already have infiltrated adjacent tissues thus requiring very aggressive treatments with serious side effects. Here we use electrochemotherapy (ECT), a well demonstrated treatment modality for superficial tumors. Materials and methods: In the case of deep-seated tumors, the main limitation of ECT is reaching the tumor with an appropriate electric field. To overcome this limitation we introduce the single needle electrode (SiNE), a minimally invasive device that can deliver an appropriate electric field with a simple procedure. Twenty-one canine patients with spontaneous tumors were selected, eleven were treated using the SiNE with ECT, and ten with surgery plus adjuvant chemotherapy as a control group. Results: In the SiNE group, 27% achieved a complete response, 64% had a partial response, and 9% had a stable disease. This means that 91% of objective responses were obtained. The mean overall survival was 16.86 months (4–32 months, median 16.5 months), with a survival rate significantly higher (p = 0.0008) when compared with control group. The only side effect observed was the inflammation of the treated nasal passage, which was controlled with corticosteroid therapy for one week. One year after the treatment, 60% of the canine of the SiNE group vs. 10% of the control group remained alive, and after the 32 months follow-up, the survival rate were 30% and 0%, respectively. Conclusions: ECT with the SiNE can be safely used in canine to treat nasal tumors with encouraging results.
dc.format application/pdf
dc.language.iso eng
dc.publisher Association of Radiology and Oncology
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject ELECTROCHEMOTHERAPY
dc.subject NASAL CAVITY
dc.subject CANINE
dc.subject CANCER
dc.subject.classification Medicina Critica y de Emergencia
dc.subject.classification Medicina Clínica
dc.subject.classification CIENCIAS MÉDICAS Y DE LA SALUD
dc.subject.classification Otras Ciencias Veterinarias
dc.subject.classification Ciencias Veterinarias
dc.subject.classification CIENCIAS AGRÍCOLAS
dc.subject.classification Ingeniería Médica
dc.subject.classification Ingeniería Médica
dc.subject.classification INGENIERÍAS Y TECNOLOGÍAS
dc.title Minimally invasive electrochemotherapy procedure for treating nasal duct tumors in dogs using a single needle electrode
dc.type info:eu-repo/semantics/article
dc.type info:ar-repo/semantics/artículo
dc.type info:eu-repo/semantics/publishedVersion
dc.date.updated 2018-04-03T18:43:27Z
dc.identifier.eissn 1581-3207
dc.journal.volume 51
dc.journal.number 4
dc.journal.pagination 1-9
dc.journal.pais Eslovenia
dc.journal.ciudad Ljubljana
dc.description.fil Fil: Maglietti, Felipe Horacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física del Plasma. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física del Plasma; Argentina
dc.description.fil Fil: Tellado, Matías Nicolás. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
dc.description.fil Fil: Olaiz, Nahuel Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física del Plasma. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física del Plasma; Argentina
dc.description.fil Fil: Michinski, Sebastián Diego. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física del Plasma. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física del Plasma; Argentina
dc.description.fil Fil: Marshall, Guillermo Ricardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física del Plasma. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física del Plasma; Argentina
dc.journal.title Radiology and Oncology
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/http://www.degruyter.com/view/j/raon.ahead-of-print/raon-2017-0043/raon-2017-0043.xml
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1515/raon-2017-0043
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Atribución-NoComercial-SinDerivadas 2.5 Argentina (CC BY-NC-ND 2.5 AR)