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dc.contributor.author
Carranza, Pedro Gabriel
dc.contributor.author
Gargantini, Pablo Ruben
dc.contributor.author
Prucca, Cesar German
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Torri, Alessandro
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Saura, Alicia
dc.contributor.author
Svärd, Staffan
dc.contributor.author
Lujan, Hugo Daniel
dc.date.available
2018-04-03T22:02:40Z
dc.date.issued
2016-12
dc.identifier.citation
Carranza, Pedro Gabriel; Gargantini, Pablo Ruben; Prucca, Cesar German; Torri, Alessandro; Saura, Alicia; et al.; Specific histone modifications play critical roles in the control of encystation and antigenic variation in the early-branching eukaryote Giardia lamblia; Pergamon-Elsevier Science Ltd; International Journal Of Biochemistry And Cellular Biology; 81; Part A; 12-2016; 32-43
dc.identifier.issn
1357-2725
dc.identifier.uri
http://hdl.handle.net/11336/40613
dc.description.abstract
During evolution, parasitic microorganisms have faced the challenges of adapting to different environments to colonize a variety of hosts. Giardia lamblia, a common cause of intestinal disease, has developed fascinating strategies to adapt both outside and inside its host´s intestine, such as trophozoite differentiation into cyst and the switching of its major surface antigens. How gene expression is regulated during these adaptive processes remains undefined. Giardia lacks some typical eukaryotic features, like canonical transcription factors, linker histone H1, and complex promoter regions; suggesting that post-transcriptional and translational control of gene expression is essential for parasite survival. However, epigenetic factors may also play critical roles at the transcriptional level. Here, we describe the most common post-translational histone modifications; characterize enzymes involved in these reactions, and analyze their association with the Giardia´s differentiation processes. We present evidence that NAD+-dependent and NAD+-independent histone deacetylases regulate encystation; however, a unique NAD+-independent histone deacetylase modulate antigenic switching. The rates of acetylation of H4K8 and H4K16 are critical for encystation, whereas a decrease in acetylation of H4K8 and methylation of H3K9 occur preferentially during antigenic variation. These results show the complexity of the mechanisms regulating gene expression in this minimalistic protozoan parasite.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Pergamon-Elsevier Science Ltd
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Cellular Differentiation
dc.subject
Gene Regulation
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Hdac
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Histone Deacetylases
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Histone Marks
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Histone Methylases
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Sirtuin
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Otras Ciencias Biológicas
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Specific histone modifications play critical roles in the control of encystation and antigenic variation in the early-branching eukaryote Giardia lamblia
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-04-03T18:24:41Z
dc.journal.volume
81
dc.journal.number
Part A
dc.journal.pagination
32-43
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Carranza, Pedro Gabriel. Universidad Católica de Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Gargantini, Pablo Ruben. Universidad Católica de Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigación y Desarrollo En Inmunología y Enfermedades Infecciosas. Universidad Catolica de Córdoba. Centro de Investigación y Desarrollo En Inmunología y Enfermedades Infecciosas; Argentina
dc.description.fil
Fil: Prucca, Cesar German. Universidad Católica de Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Torri, Alessandro. Universidad Católica de Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Saura, Alicia. Universidad Católica de Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigación y Desarrollo En Inmunología y Enfermedades Infecciosas. Universidad Catolica de Córdoba. Centro de Investigación y Desarrollo En Inmunología y Enfermedades Infecciosas; Argentina
dc.description.fil
Fil: Svärd, Staffan. Uppsala University; Suecia
dc.description.fil
Fil: Lujan, Hugo Daniel. Universidad Católica de Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigación y Desarrollo En Inmunología y Enfermedades Infecciosas. Universidad Catolica de Córdoba. Centro de Investigación y Desarrollo En Inmunología y Enfermedades Infecciosas; Argentina
dc.journal.title
International Journal Of Biochemistry And Cellular Biology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.biocel.2016.10.010
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1357272516303132
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