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dc.contributor.author
Garcia Rill, Edgar
dc.contributor.author
Luster, Brennon
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D'Onofrio, S.
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Mahaffey, Susan
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Bisagno, Veronica
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Urbano Suarez, Francisco Jose
dc.date.available
2018-03-28T19:26:09Z
dc.date.issued
2016-07
dc.identifier.citation
Garcia Rill, Edgar; Luster, Brennon; D'Onofrio, S.; Mahaffey, Susan; Bisagno, Veronica; et al.; Implications of gamma band activity in the pedunculopontine nucleus; Springer Wien; Journal of Neural Transmission. General Section; 123; 7; 7-2016; 655-665
dc.identifier.issn
0300-9564
dc.identifier.uri
http://hdl.handle.net/11336/40458
dc.description.abstract
The fact that the pedunculopontine nucleus (PPN) is part of the reticular activating system places it in a unique position to modulate sensory input and fight-or-flight responses. Arousing stimuli simultaneously activate ascending projections of the PPN to the intralaminar thalamus to trigger cortical high-frequency activity and arousal, as well as descending projections to reticulospinal systems to alter posture and locomotion. As such, the PPN has become a target for deep brain stimulation for the treatment of Parkinson’s disease, modulating gait, posture, and higher functions. This article describes the latest discoveries on PPN physiology and the role of the PPN in a number of disorders. It has now been determined that high-frequency activity during waking and REM sleep is controlled by two different intracellular pathways and two calcium channels in PPN cells. Moreover, there are three different PPN cell types that have one or both calcium channels and may be active during waking only, REM sleep only, or both. Based on the new discoveries, novel mechanisms are proposed for insomnia as a waking disorder. In addition, neuronal calcium sensor protein-1 (NCS-1), which is over expressed in schizophrenia and bipolar disorder, may be responsible for the dysregulation in gamma band activity in at least some patients with these diseases. Recent results suggest that NCS-1 modulates PPN gamma band activity and that lithium acts to reduce the effects of over expressed NCS-1, accounting for its effectiveness in bipolar disorder.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Springer Wien
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Arousal
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Gamma Oscillations
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N-Type
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P/Q-Type
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Sleep/Wake
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Neurociencias
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Implications of gamma band activity in the pedunculopontine nucleus
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-03-28T14:11:15Z
dc.identifier.eissn
1435-1463
dc.journal.volume
123
dc.journal.number
7
dc.journal.pagination
655-665
dc.journal.pais
Austria
dc.journal.ciudad
Viena
dc.description.fil
Fil: Garcia Rill, Edgar. University of Arkansas for Medical Sciences; Estados Unidos
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Fil: Luster, Brennon. University of Arkansas for Medical Sciences; Estados Unidos
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Fil: D'Onofrio, S.. University of Arkansas for Medical Sciences; Estados Unidos
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Fil: Mahaffey, Susan. University of Arkansas for Medical Sciences; Estados Unidos
dc.description.fil
Fil: Bisagno, Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Farmacológicas. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Investigaciones Farmacológicas; Argentina
dc.description.fil
Fil: Urbano Suarez, Francisco Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Farmacológicas. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Investigaciones Farmacológicas; Argentina
dc.journal.title
Journal of Neural Transmission. General Section
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://link.springer.com/article/10.1007/s00702-015-1485-2
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/s00702-015-1485-2
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://pubmed.ncbi.nlm.nih.gov/26597124/
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